Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)
PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs. A prospective clinical study of 5 patients (10 ey...
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| Veröffentlicht in: | European journal of ophthalmology 2013-03, Vol.23 (2), p.156-163 |
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| container_title | European journal of ophthalmology |
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| creator | Beirão, João M Matos, Maria E Beirão, Idalina B Costa, Paulo P Torres, Paulo A |
| description | PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs.
A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months.
Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p |
| doi_str_mv | 10.5301/ejo.5000197 |
| format | Article |
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A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months.
Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events.
Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.5301/ejo.5000197</identifier><identifier>PMID: 23065854</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Topical ; Adult ; Amyloid - genetics ; Amyloid Neuropathies, Familial - epidemiology ; Amyloid Neuropathies, Familial - genetics ; Amyloid Neuropathies, Familial - surgery ; Cyclosporine - administration & dosage ; Cyclosporine - therapeutic use ; Female ; Fluorescein - metabolism ; Humans ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - therapeutic use ; Keratoconjunctivitis Sicca - drug therapy ; Keratoconjunctivitis Sicca - physiopathology ; Liver Transplantation ; Male ; Middle Aged ; Ophthalmic Solutions ; Portugal - epidemiology ; Prealbumin - genetics ; Prospective Studies ; Staining and Labeling ; Tears - physiology ; Visual Acuity - physiology</subject><ispartof>European journal of ophthalmology, 2013-03, Vol.23 (2), p.156-163</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-cfe3c7691859d0bbe931b185967d9cb18aaa299cf4e35192c1799df6dfcd9c083</citedby><cites>FETCH-LOGICAL-c289t-cfe3c7691859d0bbe931b185967d9cb18aaa299cf4e35192c1799df6dfcd9c083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23065854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beirão, João M</creatorcontrib><creatorcontrib>Matos, Maria E</creatorcontrib><creatorcontrib>Beirão, Idalina B</creatorcontrib><creatorcontrib>Costa, Paulo P</creatorcontrib><creatorcontrib>Torres, Paulo A</creatorcontrib><title>Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs.
A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months.
Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events.
Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Amyloid - genetics</subject><subject>Amyloid Neuropathies, Familial - epidemiology</subject><subject>Amyloid Neuropathies, Familial - genetics</subject><subject>Amyloid Neuropathies, Familial - surgery</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - therapeutic use</subject><subject>Female</subject><subject>Fluorescein - metabolism</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Keratoconjunctivitis Sicca - drug therapy</subject><subject>Keratoconjunctivitis Sicca - physiopathology</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ophthalmic Solutions</subject><subject>Portugal - epidemiology</subject><subject>Prealbumin - genetics</subject><subject>Prospective Studies</subject><subject>Staining and Labeling</subject><subject>Tears - physiology</subject><subject>Visual Acuity - physiology</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMojo6u3EuWinRM0tdkOQy-YESR6rak6Y2TIW1K0ir9Ef5nM8zo6p7L-TiLD6ELSmZpTOgtbOwsJYRQnh-gE5qzJMoIzQ5DpoxEWc7oBJ16vyGEEZ6wYzRhMcnSeZqcoJ_CdloKg-UojfWddboFrKzDHr7AAa7diGEMV3sQHrBusdGhiXonWt8Z0fZQ41fr-uFzgAB0otfQ9h5_636NlWi00WFfNKOxura9lrizZmxhcDaw6xFfLYri7SMmz9dn6EgJ4-F8f6fo_f6uWD5Gq5eHp-ViFUk2530kFcQyzzidp7wmVQU8ptX2yfKay5CEEIxzqRKIU8qZpDnntcpqJUNP5vEU3ex2pbPeO1Bl53Qj3FhSUm6llkFquZca6Msd3Q1VA_U_-2cx_gV5BnZR</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Beirão, João M</creator><creator>Matos, Maria E</creator><creator>Beirão, Idalina B</creator><creator>Costa, Paulo P</creator><creator>Torres, Paulo A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130301</creationdate><title>Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)</title><author>Beirão, João M ; Matos, Maria E ; Beirão, Idalina B ; Costa, Paulo P ; Torres, Paulo A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-cfe3c7691859d0bbe931b185967d9cb18aaa299cf4e35192c1799df6dfcd9c083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Amyloid - genetics</topic><topic>Amyloid Neuropathies, Familial - epidemiology</topic><topic>Amyloid Neuropathies, Familial - genetics</topic><topic>Amyloid Neuropathies, Familial - surgery</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - therapeutic use</topic><topic>Female</topic><topic>Fluorescein - metabolism</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Keratoconjunctivitis Sicca - drug therapy</topic><topic>Keratoconjunctivitis Sicca - physiopathology</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ophthalmic Solutions</topic><topic>Portugal - epidemiology</topic><topic>Prealbumin - genetics</topic><topic>Prospective Studies</topic><topic>Staining and Labeling</topic><topic>Tears - physiology</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beirão, João M</creatorcontrib><creatorcontrib>Matos, Maria E</creatorcontrib><creatorcontrib>Beirão, Idalina B</creatorcontrib><creatorcontrib>Costa, Paulo P</creatorcontrib><creatorcontrib>Torres, Paulo A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beirão, João M</au><au>Matos, Maria E</au><au>Beirão, Idalina B</au><au>Costa, Paulo P</au><au>Torres, Paulo A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>156</spage><epage>163</epage><pages>156-163</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs.
A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months.
Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events.
Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.</abstract><cop>United States</cop><pmid>23065854</pmid><doi>10.5301/ejo.5000197</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; SAGE Complete |
| subjects | Administration, Topical Adult Amyloid - genetics Amyloid Neuropathies, Familial - epidemiology Amyloid Neuropathies, Familial - genetics Amyloid Neuropathies, Familial - surgery Cyclosporine - administration & dosage Cyclosporine - therapeutic use Female Fluorescein - metabolism Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Keratoconjunctivitis Sicca - drug therapy Keratoconjunctivitis Sicca - physiopathology Liver Transplantation Male Middle Aged Ophthalmic Solutions Portugal - epidemiology Prealbumin - genetics Prospective Studies Staining and Labeling Tears - physiology Visual Acuity - physiology |
| title | Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M) |
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