Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma
Purpose To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers. Methods Paraffin sections from 35 primary uveal melanomas were evaluated immunohistochemically for th...
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| Veröffentlicht in: | European journal of ophthalmology 2011-09, Vol.21 (5), p.615-624 |
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| container_title | European journal of ophthalmology |
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| creator | Lüke, Julia Wegner, Jürgen Wegner, Rayime Nassar, Khaled Tatar, Olcay Rohrbach, Jens M. Hilgers, Ralf-Dieter Lüke, Matthias Grisanti, Salvatore |
| description | Purpose
To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers.
Methods
Paraffin sections from 35 primary uveal melanomas were evaluated immunohistochemically for the expression of c-Kit and SCF. Sixteen cases developed systemic metastasis during the follow-up (median: 5 years after diagnosis). The patients who did not develop metastasis (n=19) had a mean follow-up of 10.6 (9–13) years. Radiation was performed in 6 patients.
Results
c-Kit and SCF were expressed in all patients who did or did not develop metastasis in the further clinical course. A mean SCF expression of 77.2% (range 52.7%-97.5%) of tumors that did not develop systemic metastasis and 30.1 % (range 2.9%-61.5%) of tumors with systemic metastasis were evident. Uveal melanomas revealing an increased SCF expression were found to develop no metastasis more frequently (p |
| doi_str_mv | 10.5301/EJO.2011.6292 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_5301_EJO_2011_6292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.5301_EJO.2011.6292</sage_id><sourcerecordid>10.5301_EJO.2011.6292</sourcerecordid><originalsourceid>FETCH-LOGICAL-c327t-bb934d8f897144d7fad0096103a3310546b40668a7b1f44c8995827dfd33a8c3</originalsourceid><addsrcrecordid>eNp1kD1PwzAURS0EoqUwsiLPSC7v2a4db6Co5auoSJTZcuK4StUmVdwi-PckCrAxvTscXd13CLlEGE8E4M30aTHmgDhW3PAjMkTNJVOA6rjNyIEpzXFAzmJcA3Awkp-SAUeujdFiSG6nn7umiLGsK1oHmrLnck9d5Wm5j3Rerrr4ls5oWdHXpty65ou-fxRuQ1-KjavqrTsnJ8FtYnHxc0dkOZsu0wc2X9w_pndzlguu9yzLjJA-CYnRKKXXwXkAoxCEEwJhIlUmQanE6QyDlHlizCTh2gcvhEtyMSKsr82bOsamCHbXz7EIthNhWxG2E2E7ES1_1fO7Q7Yt_B_9-3kLXPdAdKvCrutDU7Xz_2n7Bj4SYtw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Lüke, Julia ; Wegner, Jürgen ; Wegner, Rayime ; Nassar, Khaled ; Tatar, Olcay ; Rohrbach, Jens M. ; Hilgers, Ralf-Dieter ; Lüke, Matthias ; Grisanti, Salvatore</creator><creatorcontrib>Lüke, Julia ; Wegner, Jürgen ; Wegner, Rayime ; Nassar, Khaled ; Tatar, Olcay ; Rohrbach, Jens M. ; Hilgers, Ralf-Dieter ; Lüke, Matthias ; Grisanti, Salvatore</creatorcontrib><description>Purpose
To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers.
Methods
Paraffin sections from 35 primary uveal melanomas were evaluated immunohistochemically for the expression of c-Kit and SCF. Sixteen cases developed systemic metastasis during the follow-up (median: 5 years after diagnosis). The patients who did not develop metastasis (n=19) had a mean follow-up of 10.6 (9–13) years. Radiation was performed in 6 patients.
Results
c-Kit and SCF were expressed in all patients who did or did not develop metastasis in the further clinical course. A mean SCF expression of 77.2% (range 52.7%-97.5%) of tumors that did not develop systemic metastasis and 30.1 % (range 2.9%-61.5%) of tumors with systemic metastasis were evident. Uveal melanomas revealing an increased SCF expression were found to develop no metastasis more frequently (p<0.0001; hazard ratio (HR)=0.963, 95% confidence interval (CI) 0.945–0.981). A mean c-Kit expression of 58.01% (range 5.9%-97.9%) in the group who did not develop metastasis and 48.9% (range 5.0%-95.9%) in the group with systemic metastasis were observed. c-Kit expression was not associated with increased rates of metastasis formation (p=0.7329; HR=0.997, 95% CI 0.982–1.013). The correlation between SCF and c-Kit is weak (0.39; 95% CI 0.06–0.63).
Conclusions
c-Kit expression was not found to be associated with metastasis formation. A high SCF expression of primary choroidal melanomas was significantly associated with a lower incidence of systemic metastasis, which indicated SCF as a benign prognostic factor in the further clinical course.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.5301/EJO.2011.6292</identifier><identifier>PMID: 21279973</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Female ; Humans ; Immunoenzyme Techniques ; Liver Neoplasms - metabolism ; Liver Neoplasms - radiotherapy ; Liver Neoplasms - secondary ; Male ; Melanoma - metabolism ; Melanoma - radiotherapy ; Melanoma - secondary ; Middle Aged ; Neoplasm Staging ; Proto-Oncogene Proteins c-kit - metabolism ; Stem Cell Factor - metabolism ; Uveal Neoplasms - metabolism ; Uveal Neoplasms - pathology ; Uveal Neoplasms - radiotherapy</subject><ispartof>European journal of ophthalmology, 2011-09, Vol.21 (5), p.615-624</ispartof><rights>2011 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-bb934d8f897144d7fad0096103a3310546b40668a7b1f44c8995827dfd33a8c3</citedby><cites>FETCH-LOGICAL-c327t-bb934d8f897144d7fad0096103a3310546b40668a7b1f44c8995827dfd33a8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/EJO.2011.6292$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/EJO.2011.6292$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21279973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lüke, Julia</creatorcontrib><creatorcontrib>Wegner, Jürgen</creatorcontrib><creatorcontrib>Wegner, Rayime</creatorcontrib><creatorcontrib>Nassar, Khaled</creatorcontrib><creatorcontrib>Tatar, Olcay</creatorcontrib><creatorcontrib>Rohrbach, Jens M.</creatorcontrib><creatorcontrib>Hilgers, Ralf-Dieter</creatorcontrib><creatorcontrib>Lüke, Matthias</creatorcontrib><creatorcontrib>Grisanti, Salvatore</creatorcontrib><title>Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose
To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers.
Methods
Paraffin sections from 35 primary uveal melanomas were evaluated immunohistochemically for the expression of c-Kit and SCF. Sixteen cases developed systemic metastasis during the follow-up (median: 5 years after diagnosis). The patients who did not develop metastasis (n=19) had a mean follow-up of 10.6 (9–13) years. Radiation was performed in 6 patients.
Results
c-Kit and SCF were expressed in all patients who did or did not develop metastasis in the further clinical course. A mean SCF expression of 77.2% (range 52.7%-97.5%) of tumors that did not develop systemic metastasis and 30.1 % (range 2.9%-61.5%) of tumors with systemic metastasis were evident. Uveal melanomas revealing an increased SCF expression were found to develop no metastasis more frequently (p<0.0001; hazard ratio (HR)=0.963, 95% confidence interval (CI) 0.945–0.981). A mean c-Kit expression of 58.01% (range 5.9%-97.9%) in the group who did not develop metastasis and 48.9% (range 5.0%-95.9%) in the group with systemic metastasis were observed. c-Kit expression was not associated with increased rates of metastasis formation (p=0.7329; HR=0.997, 95% CI 0.982–1.013). The correlation between SCF and c-Kit is weak (0.39; 95% CI 0.06–0.63).
Conclusions
c-Kit expression was not found to be associated with metastasis formation. A high SCF expression of primary choroidal melanomas was significantly associated with a lower incidence of systemic metastasis, which indicated SCF as a benign prognostic factor in the further clinical course.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - radiotherapy</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - radiotherapy</subject><subject>Melanoma - secondary</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Stem Cell Factor - metabolism</subject><subject>Uveal Neoplasms - metabolism</subject><subject>Uveal Neoplasms - pathology</subject><subject>Uveal Neoplasms - radiotherapy</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EoqUwsiLPSC7v2a4db6Co5auoSJTZcuK4StUmVdwi-PckCrAxvTscXd13CLlEGE8E4M30aTHmgDhW3PAjMkTNJVOA6rjNyIEpzXFAzmJcA3Awkp-SAUeujdFiSG6nn7umiLGsK1oHmrLnck9d5Wm5j3Rerrr4ls5oWdHXpty65ou-fxRuQ1-KjavqrTsnJ8FtYnHxc0dkOZsu0wc2X9w_pndzlguu9yzLjJA-CYnRKKXXwXkAoxCEEwJhIlUmQanE6QyDlHlizCTh2gcvhEtyMSKsr82bOsamCHbXz7EIthNhWxG2E2E7ES1_1fO7Q7Yt_B_9-3kLXPdAdKvCrutDU7Xz_2n7Bj4SYtw</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Lüke, Julia</creator><creator>Wegner, Jürgen</creator><creator>Wegner, Rayime</creator><creator>Nassar, Khaled</creator><creator>Tatar, Olcay</creator><creator>Rohrbach, Jens M.</creator><creator>Hilgers, Ralf-Dieter</creator><creator>Lüke, Matthias</creator><creator>Grisanti, Salvatore</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201109</creationdate><title>Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma</title><author>Lüke, Julia ; Wegner, Jürgen ; Wegner, Rayime ; Nassar, Khaled ; Tatar, Olcay ; Rohrbach, Jens M. ; Hilgers, Ralf-Dieter ; Lüke, Matthias ; Grisanti, Salvatore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-bb934d8f897144d7fad0096103a3310546b40668a7b1f44c8995827dfd33a8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - radiotherapy</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - radiotherapy</topic><topic>Melanoma - secondary</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Stem Cell Factor - metabolism</topic><topic>Uveal Neoplasms - metabolism</topic><topic>Uveal Neoplasms - pathology</topic><topic>Uveal Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lüke, Julia</creatorcontrib><creatorcontrib>Wegner, Jürgen</creatorcontrib><creatorcontrib>Wegner, Rayime</creatorcontrib><creatorcontrib>Nassar, Khaled</creatorcontrib><creatorcontrib>Tatar, Olcay</creatorcontrib><creatorcontrib>Rohrbach, Jens M.</creatorcontrib><creatorcontrib>Hilgers, Ralf-Dieter</creatorcontrib><creatorcontrib>Lüke, Matthias</creatorcontrib><creatorcontrib>Grisanti, Salvatore</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lüke, Julia</au><au>Wegner, Jürgen</au><au>Wegner, Rayime</au><au>Nassar, Khaled</au><au>Tatar, Olcay</au><au>Rohrbach, Jens M.</au><au>Hilgers, Ralf-Dieter</au><au>Lüke, Matthias</au><au>Grisanti, Salvatore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2011-09</date><risdate>2011</risdate><volume>21</volume><issue>5</issue><spage>615</spage><epage>624</epage><pages>615-624</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers.
Methods
Paraffin sections from 35 primary uveal melanomas were evaluated immunohistochemically for the expression of c-Kit and SCF. Sixteen cases developed systemic metastasis during the follow-up (median: 5 years after diagnosis). The patients who did not develop metastasis (n=19) had a mean follow-up of 10.6 (9–13) years. Radiation was performed in 6 patients.
Results
c-Kit and SCF were expressed in all patients who did or did not develop metastasis in the further clinical course. A mean SCF expression of 77.2% (range 52.7%-97.5%) of tumors that did not develop systemic metastasis and 30.1 % (range 2.9%-61.5%) of tumors with systemic metastasis were evident. Uveal melanomas revealing an increased SCF expression were found to develop no metastasis more frequently (p<0.0001; hazard ratio (HR)=0.963, 95% confidence interval (CI) 0.945–0.981). A mean c-Kit expression of 58.01% (range 5.9%-97.9%) in the group who did not develop metastasis and 48.9% (range 5.0%-95.9%) in the group with systemic metastasis were observed. c-Kit expression was not associated with increased rates of metastasis formation (p=0.7329; HR=0.997, 95% CI 0.982–1.013). The correlation between SCF and c-Kit is weak (0.39; 95% CI 0.06–0.63).
Conclusions
c-Kit expression was not found to be associated with metastasis formation. A high SCF expression of primary choroidal melanomas was significantly associated with a lower incidence of systemic metastasis, which indicated SCF as a benign prognostic factor in the further clinical course.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21279973</pmid><doi>10.5301/EJO.2011.6292</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1120-6721 |
| ispartof | European journal of ophthalmology, 2011-09, Vol.21 (5), p.615-624 |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Female Humans Immunoenzyme Techniques Liver Neoplasms - metabolism Liver Neoplasms - radiotherapy Liver Neoplasms - secondary Male Melanoma - metabolism Melanoma - radiotherapy Melanoma - secondary Middle Aged Neoplasm Staging Proto-Oncogene Proteins c-kit - metabolism Stem Cell Factor - metabolism Uveal Neoplasms - metabolism Uveal Neoplasms - pathology Uveal Neoplasms - radiotherapy |
| title | Expression of C-Kit and its Ligand SCF in Primary Uveal Melanoma |
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