Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos
The relative risk of mesothelioma associated with different levels of exposure to asbestos was evaluated. The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two refer...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1991-12, Vol.17 (6), p.404-408 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
| container_volume | 17 |
| creator | Tuomi, Timo Huuskonen, Matti S Virtamo, Matti Tossavainen, Antti Tammilehto, Lauri Mattson, Karin Lahdensuo, Aarne Mattila, Jorma Karhunen, Pekka Liippo, Kari Tala, Eero |
| description | The relative risk of mesothelioma associated with different levels of exposure to asbestos was evaluated. The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two reference groups (13 random autopsy cases and 43 male lung cancer patients). When the categories definite and probable were used as an estimated probability of occupational exposure, an odds ratio of 17.7 [90 % confidence interval (90 % CI) 3.4—253] and 3.0 (90 % CI 0.9—10.6), respectively, was obtained. A lung fiber concentration of > 1 million fibers/g of dry tissue as an indicator of accumulated exposure gave an odds ratio of 14.4 (90 % CI 2.5—178) for the men in comparison with the autopsy cases and 3.1 (90 % CI, 1.3—7.5) in comparison with the lung cancer patients. Elevated risk of mesothelioma was shown to be associated with a lung fiber concentration of > 1 million fibers/g of dry tissue. |
| doi_str_mv | 10.5271/sjweh.1686 |
| format | Article |
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The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two reference groups (13 random autopsy cases and 43 male lung cancer patients). When the categories definite and probable were used as an estimated probability of occupational exposure, an odds ratio of 17.7 [90 % confidence interval (90 % CI) 3.4—253] and 3.0 (90 % CI 0.9—10.6), respectively, was obtained. A lung fiber concentration of > 1 million fibers/g of dry tissue as an indicator of accumulated exposure gave an odds ratio of 14.4 (90 % CI 2.5—178) for the men in comparison with the autopsy cases and 3.1 (90 % CI, 1.3—7.5) in comparison with the lung cancer patients. Elevated risk of mesothelioma was shown to be associated with a lung fiber concentration of > 1 million fibers/g of dry tissue.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>DOI: 10.5271/sjweh.1686</identifier><identifier>PMID: 1788534</identifier><language>eng</language><publisher>Helsinki: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Adult ; Aged ; Asbestos ; Asbestos - adverse effects ; Asbestosis - pathology ; Autopsies ; Biological and medical sciences ; Cell Transformation, Neoplastic - pathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Humans ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Lung - pathology ; Lung Diseases - pathology ; Lung neoplasms ; Lung Neoplasms - pathology ; Lungs ; Male ; Medical sciences ; Men ; Mesothelioma ; Mesothelioma - pathology ; Microscopy, Electron ; Middle Aged ; Occupational Exposure ; Patient medical history ; Ratios ; Referents ; Risk Factors ; Sarcoidosis ; Sarcoidosis - pathology ; Smoking - adverse effects ; Smoking - pathology ; Toxicology</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1991-12, Vol.17 (6), p.404-408</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a434t-c6931d3e9366c50ed86572b5e80349e158810570326a5a03b350b02b3c8e82b83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40965926$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40965926$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5349646$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1788534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuomi, Timo</creatorcontrib><creatorcontrib>Huuskonen, Matti S</creatorcontrib><creatorcontrib>Virtamo, Matti</creatorcontrib><creatorcontrib>Tossavainen, Antti</creatorcontrib><creatorcontrib>Tammilehto, Lauri</creatorcontrib><creatorcontrib>Mattson, Karin</creatorcontrib><creatorcontrib>Lahdensuo, Aarne</creatorcontrib><creatorcontrib>Mattila, Jorma</creatorcontrib><creatorcontrib>Karhunen, Pekka</creatorcontrib><creatorcontrib>Liippo, Kari</creatorcontrib><creatorcontrib>Tala, Eero</creatorcontrib><title>Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>The relative risk of mesothelioma associated with different levels of exposure to asbestos was evaluated. The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two reference groups (13 random autopsy cases and 43 male lung cancer patients). When the categories definite and probable were used as an estimated probability of occupational exposure, an odds ratio of 17.7 [90 % confidence interval (90 % CI) 3.4—253] and 3.0 (90 % CI 0.9—10.6), respectively, was obtained. A lung fiber concentration of > 1 million fibers/g of dry tissue as an indicator of accumulated exposure gave an odds ratio of 14.4 (90 % CI 2.5—178) for the men in comparison with the autopsy cases and 3.1 (90 % CI, 1.3—7.5) in comparison with the lung cancer patients. Elevated risk of mesothelioma was shown to be associated with a lung fiber concentration of > 1 million fibers/g of dry tissue.</description><subject>Adult</subject><subject>Aged</subject><subject>Asbestos</subject><subject>Asbestos - adverse effects</subject><subject>Asbestosis - pathology</subject><subject>Autopsies</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Humans</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Lung - pathology</subject><subject>Lung Diseases - pathology</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - pathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Mesothelioma</subject><subject>Mesothelioma - pathology</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Patient medical history</subject><subject>Ratios</subject><subject>Referents</subject><subject>Risk Factors</subject><subject>Sarcoidosis</subject><subject>Sarcoidosis - pathology</subject><subject>Smoking - adverse effects</subject><subject>Smoking - pathology</subject><subject>Toxicology</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1PGzEQhq0KlAbaS--V9sCp0sJ4_bH2EVEKSEFICKreLO9mVnHYxJHtJOXf4yUowMEaWc8zI807hPygcCqqmp7F-RZnp1Qq-YWMaa1FqTX8OyBjYEKUjHL4So5inANUOjeMyIjWSgnGx-TvPfY2uQ0W9y4-Fb4rbjH6NMPe-YUtzmP0rbMJp8XWpVnx23UdBlymYoIb7OPQcPl_5eM6YJF89huMycdv5LCzfcTvb_WYPP65fLi4Lid3VzcX55PScsZT2UrN6JShZlK2AnCqpKirRqACxjVSoRQFUQOrpBUWWMMENFA1rFWoqkaxY_JrN7cNPsaAnVkFt7Dh2VAwQzbmNRszZJPlnzt5tW4WOH1Xd2FkfvLGbWxt3wW7bF3ca1nRkn8YM8-bhj3moKXQ1cCvd9y64JIzc78OyxyCGa4xHMNQrSmlpgIKuSoAWX_-cOD5KfYCJ66JKA</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Tuomi, Timo</creator><creator>Huuskonen, Matti S</creator><creator>Virtamo, Matti</creator><creator>Tossavainen, Antti</creator><creator>Tammilehto, Lauri</creator><creator>Mattson, Karin</creator><creator>Lahdensuo, Aarne</creator><creator>Mattila, Jorma</creator><creator>Karhunen, Pekka</creator><creator>Liippo, Kari</creator><creator>Tala, Eero</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute of Occupational Health (Sweden)</general><general>Institute of Occupational Health (Finland)</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><general>Scandinavian journal of work, environment & health</general><scope>188</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19911201</creationdate><title>Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos</title><author>Tuomi, Timo ; Huuskonen, Matti S ; Virtamo, Matti ; Tossavainen, Antti ; Tammilehto, Lauri ; Mattson, Karin ; Lahdensuo, Aarne ; Mattila, Jorma ; Karhunen, Pekka ; Liippo, Kari ; Tala, Eero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a434t-c6931d3e9366c50ed86572b5e80349e158810570326a5a03b350b02b3c8e82b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asbestos</topic><topic>Asbestos - adverse effects</topic><topic>Asbestosis - pathology</topic><topic>Autopsies</topic><topic>Biological and medical sciences</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Humans</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Lung - pathology</topic><topic>Lung Diseases - pathology</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - pathology</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Mesothelioma</topic><topic>Mesothelioma - pathology</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Occupational Exposure</topic><topic>Patient medical history</topic><topic>Ratios</topic><topic>Referents</topic><topic>Risk Factors</topic><topic>Sarcoidosis</topic><topic>Sarcoidosis - pathology</topic><topic>Smoking - adverse effects</topic><topic>Smoking - pathology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuomi, Timo</creatorcontrib><creatorcontrib>Huuskonen, Matti S</creatorcontrib><creatorcontrib>Virtamo, Matti</creatorcontrib><creatorcontrib>Tossavainen, Antti</creatorcontrib><creatorcontrib>Tammilehto, Lauri</creatorcontrib><creatorcontrib>Mattson, Karin</creatorcontrib><creatorcontrib>Lahdensuo, Aarne</creatorcontrib><creatorcontrib>Mattila, Jorma</creatorcontrib><creatorcontrib>Karhunen, Pekka</creatorcontrib><creatorcontrib>Liippo, Kari</creatorcontrib><creatorcontrib>Tala, Eero</creatorcontrib><collection>Airiti Library</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuomi, Timo</au><au>Huuskonen, Matti S</au><au>Virtamo, Matti</au><au>Tossavainen, Antti</au><au>Tammilehto, Lauri</au><au>Mattson, Karin</au><au>Lahdensuo, Aarne</au><au>Mattila, Jorma</au><au>Karhunen, Pekka</au><au>Liippo, Kari</au><au>Tala, Eero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>17</volume><issue>6</issue><spage>404</spage><epage>408</epage><pages>404-408</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>The relative risk of mesothelioma associated with different levels of exposure to asbestos was evaluated. The exposure was assessed from work histories of 51 mesothelioma cases and 51 sarcoidosis referents. The lung fiber concentration of the mesothelioma patients was compared with that of two reference groups (13 random autopsy cases and 43 male lung cancer patients). When the categories definite and probable were used as an estimated probability of occupational exposure, an odds ratio of 17.7 [90 % confidence interval (90 % CI) 3.4—253] and 3.0 (90 % CI 0.9—10.6), respectively, was obtained. A lung fiber concentration of > 1 million fibers/g of dry tissue as an indicator of accumulated exposure gave an odds ratio of 14.4 (90 % CI 2.5—178) for the men in comparison with the autopsy cases and 3.1 (90 % CI, 1.3—7.5) in comparison with the lung cancer patients. Elevated risk of mesothelioma was shown to be associated with a lung fiber concentration of > 1 million fibers/g of dry tissue.</abstract><cop>Helsinki</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>1788534</pmid><doi>10.5271/sjweh.1686</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0355-3140 |
| ispartof | Scandinavian Journal of Work, Environment ＆ Health, 1991-12, Vol.17 (6), p.404-408 |
| issn | 0355-3140 1795-990X |
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| source | Jstor Complete Legacy; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Asbestos Asbestos - adverse effects Asbestosis - pathology Autopsies Biological and medical sciences Cell Transformation, Neoplastic - pathology Chemical and industrial products toxicology. Toxic occupational diseases Humans Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Lung - pathology Lung Diseases - pathology Lung neoplasms Lung Neoplasms - pathology Lungs Male Medical sciences Men Mesothelioma Mesothelioma - pathology Microscopy, Electron Middle Aged Occupational Exposure Patient medical history Ratios Referents Risk Factors Sarcoidosis Sarcoidosis - pathology Smoking - adverse effects Smoking - pathology Toxicology |
| title | Relative Risk of Mesothelioma Associated with Different Levels of Exposure to Asbestos |
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