Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study
This study aimed to examine the effect of discontinuation of antipsychotic medication on the relapse of psychiatric symptoms in pregnant women with schizophrenia. We investigated the medical records of all consecutive pregnant women with schizophrenia who continuously visited and delivered their chi...
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| Veröffentlicht in: | Clinical Neuropsychopharmacology and Therapeutics 2020/10/02, Vol.11, pp.61-66 |
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| container_title | Clinical Neuropsychopharmacology and Therapeutics |
| container_volume | 11 |
| creator | Seki, Ryota Hashimoto, Tasuku Tanaka, Mami Sato, Aiko Kimura, Hiroshi Kimura, Atsushi Handa, Satoshi Kanahara, Nobuhisa Okayama, Jun Omoto, Akiko Endo, Mamiko Osone, Yoshiteru Watanabe, Hiroyuki Tanaka, Hirokazu Nakazato, Michiko Shozu, Makio Iyo, Masaomi |
| description | This study aimed to examine the effect of discontinuation of antipsychotic medication on the relapse of psychiatric symptoms in pregnant women with schizophrenia. We investigated the medical records of all consecutive pregnant women with schizophrenia who continuously visited and delivered their children at Chiba University Hospital from January 2007 to January 2019. We retrospectively assessed the scores on the Clinical Global Impression of Change scale (CGI-C) during the period when psychiatric symptoms changed most during the pregnancy. A CGI-C score of 5 or more was defined as a relapse. Twenty-eight patients consisting of the maintained treatment group (n = 18) and the discontinuation group (n= 10) were recruited. During pregnancy, the relapse rate in the maintained treatment group (16.7%) was significantly lower than that in the discontinuation group (90.0%). This study demonstrates a high relapse rate in pregnant women discontinuing their antipsychotic medication, as well as during the non-pregnancy period. |
| doi_str_mv | 10.5234/cnpt.11.61 |
| format | Article |
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We investigated the medical records of all consecutive pregnant women with schizophrenia who continuously visited and delivered their children at Chiba University Hospital from January 2007 to January 2019. We retrospectively assessed the scores on the Clinical Global Impression of Change scale (CGI-C) during the period when psychiatric symptoms changed most during the pregnancy. A CGI-C score of 5 or more was defined as a relapse. Twenty-eight patients consisting of the maintained treatment group (n = 18) and the discontinuation group (n= 10) were recruited. During pregnancy, the relapse rate in the maintained treatment group (16.7%) was significantly lower than that in the discontinuation group (90.0%). 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This study demonstrates a high relapse rate in pregnant women discontinuing their antipsychotic medication, as well as during the non-pregnancy period.</description><subject>antipsychotics</subject><subject>pregnancy</subject><subject>relapse</subject><subject>schizophrenia</subject><issn>1884-8826</issn><issn>1884-8826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpNkE1LAzEQhoMoWGov_oKcha2b3STNCh6k-AUFQXpf0nx0U7pJSFLLevWPm1qpzmVmXp55mRkArlE5JVWNb4X1aYrQlKIzMEKM4YKxip7_qy_BJMZNmYOwMosj8PWuttxHBZ2GPg6iMzwFI2Acep9cHyHXSQUoTRTOJmN3PBlnDzTP7c-ES0ZEaCz0Qa1tluHe9crCvUkdjNnx0_kuKGv4HeQwqBRc9Eok86FgTDs5XIELzbdRTX7zGCyfHpfzl2Lx9vw6f1gUoiIUFdVM4xpXBNOSNwzhWmo8w6tZKSgmfFVpuWqoJEoKqqUmtaw1E0Q2iEjCaFOPwc3RVuQFYlC69cH0PAwtKtvDA9vDA1uEWooyfH-ENzHxtTqhPORrt-qElkf-T-94aJWtvwGXkX8Y</recordid><startdate>20201002</startdate><enddate>20201002</enddate><creator>Seki, Ryota</creator><creator>Hashimoto, Tasuku</creator><creator>Tanaka, Mami</creator><creator>Sato, Aiko</creator><creator>Kimura, Hiroshi</creator><creator>Kimura, Atsushi</creator><creator>Handa, Satoshi</creator><creator>Kanahara, Nobuhisa</creator><creator>Okayama, Jun</creator><creator>Omoto, Akiko</creator><creator>Endo, Mamiko</creator><creator>Osone, Yoshiteru</creator><creator>Watanabe, Hiroyuki</creator><creator>Tanaka, Hirokazu</creator><creator>Nakazato, Michiko</creator><creator>Shozu, Makio</creator><creator>Iyo, Masaomi</creator><general>The Japanese Society of Clinical Neuropsychopharmacology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201002</creationdate><title>Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study</title><author>Seki, Ryota ; Hashimoto, Tasuku ; Tanaka, Mami ; Sato, Aiko ; Kimura, Hiroshi ; Kimura, Atsushi ; Handa, Satoshi ; Kanahara, Nobuhisa ; Okayama, Jun ; Omoto, Akiko ; Endo, Mamiko ; Osone, Yoshiteru ; Watanabe, Hiroyuki ; Tanaka, Hirokazu ; Nakazato, Michiko ; Shozu, Makio ; Iyo, Masaomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2561-27f43425460a98143df474b70c645ab2fdb96d5edc6fdf53d3f8c5d915d58693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>antipsychotics</topic><topic>pregnancy</topic><topic>relapse</topic><topic>schizophrenia</topic><toplevel>online_resources</toplevel><creatorcontrib>Seki, Ryota</creatorcontrib><creatorcontrib>Hashimoto, Tasuku</creatorcontrib><creatorcontrib>Tanaka, Mami</creatorcontrib><creatorcontrib>Sato, Aiko</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><creatorcontrib>Kimura, Atsushi</creatorcontrib><creatorcontrib>Handa, Satoshi</creatorcontrib><creatorcontrib>Kanahara, Nobuhisa</creatorcontrib><creatorcontrib>Okayama, Jun</creatorcontrib><creatorcontrib>Omoto, Akiko</creatorcontrib><creatorcontrib>Endo, Mamiko</creatorcontrib><creatorcontrib>Osone, Yoshiteru</creatorcontrib><creatorcontrib>Watanabe, Hiroyuki</creatorcontrib><creatorcontrib>Tanaka, Hirokazu</creatorcontrib><creatorcontrib>Nakazato, Michiko</creatorcontrib><creatorcontrib>Shozu, Makio</creatorcontrib><creatorcontrib>Iyo, Masaomi</creatorcontrib><collection>CrossRef</collection><jtitle>Clinical Neuropsychopharmacology and Therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seki, Ryota</au><au>Hashimoto, Tasuku</au><au>Tanaka, Mami</au><au>Sato, Aiko</au><au>Kimura, Hiroshi</au><au>Kimura, Atsushi</au><au>Handa, Satoshi</au><au>Kanahara, Nobuhisa</au><au>Okayama, Jun</au><au>Omoto, Akiko</au><au>Endo, Mamiko</au><au>Osone, Yoshiteru</au><au>Watanabe, Hiroyuki</au><au>Tanaka, Hirokazu</au><au>Nakazato, Michiko</au><au>Shozu, Makio</au><au>Iyo, Masaomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study</atitle><jtitle>Clinical Neuropsychopharmacology and Therapeutics</jtitle><addtitle>CNPT</addtitle><date>2020-10-02</date><risdate>2020</risdate><volume>11</volume><spage>61</spage><epage>66</epage><pages>61-66</pages><issn>1884-8826</issn><eissn>1884-8826</eissn><abstract>This study aimed to examine the effect of discontinuation of antipsychotic medication on the relapse of psychiatric symptoms in pregnant women with schizophrenia. 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This study demonstrates a high relapse rate in pregnant women discontinuing their antipsychotic medication, as well as during the non-pregnancy period.</abstract><pub>The Japanese Society of Clinical Neuropsychopharmacology</pub><doi>10.5234/cnpt.11.61</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | antipsychotics pregnancy relapse schizophrenia |
| title | Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study |
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