Association of Cytokine Gene Polymorphism with Susceptibility of Ankylosing Spondylitis

This article reviews various studies on cytokine polymorphism in ankylosing spondylitis and looks for the associations between the susceptibility to disease. To find the pertinent research, a thorough search of the literature was undertaken. Articles were chosen for this review should be met some criteria: Studies should be case control studies, should described the association between the cytokine gene polymorphism (IL-1R2, IL-12B, IL-10, TNF-α and IL-23R) with the pathogenesis of AS, frequencies of genotypes and alleles in case and control groups could be collected. This article reviewed 20 different studies on Cytokine gene polymorphisms. Nine single-nucleotide polymorphisms (SNPs) of IL-23R (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, rs2201841) are linked to AS susceptibility out of the seventeen SNPs. Additionally, based on ethnicity revealed a noteworthy association between seven IL-23R SNPs and AS susceptibility in Americans and Europeans, but not in Asian population. Furthermore, susceptibility to AS is also conferred by the IL-10–819 C/T, IL-10-1082A/G, G/G genotype and TNF-α−857 C/T polymorphisms, particularly in Asian populations. IL- 1R2 in rs 2310173 polymorphism found to be associated with AS in European, not in Asian.