Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line
Many physiological, biochemical and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock in almost all organisms from bacteria to mammals. Although the substantial evidences that the circadian clock could modula...
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| Veröffentlicht in: | Annals of Cancer Research and Therapy 2010/07/30, Vol.18(1), pp.13-18 |
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| creator | Sassa, Motoki Koyama, Yoshihisa Higashimoto, Masashi Ono, Koichiro Yoshimoto, Nobuhiro Momma, Tomoyuki Saito, Masaru Ando, Jin Noda, Masaru Miyamoto, Kotaro Kobayashi, Yusuke Sugeno, Hidekazu Ishigame, Teruhide Fujita, Shotaro Ito, Testuro Sakamoto, Wataru Abe, Noriko Iwadate, Manabu Yoshida, Tuneyuki Ohshima, Takasi Takebayashi, Yuji Takenoshita, Seiichi |
| description | Many physiological, biochemical and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock in almost all organisms from bacteria to mammals. Although the substantial evidences that the circadian clock could modulate the morbidity and efficacy of anticancer therapy have been proposed, underlying mechanisms for chronotherapy has been only poorly elucidated, and it has not been popular in clinic. The aim of this study was to determine the relationship between the expression of P-glycoprotein (P-gp)/MDR1, which is one of the important molecules in anti-cancer drug resistance, and circadian rhythm in KB-C2 cells. The present study demonstrated that both MDR1 expression level and its promoter activity oscillated after treatment with high concentration of fetal bovine serum. Moreover, cytotoxic effect of taxol were dependent on the fluctuated levels of MDR1. These results suggest that the circadian rhythm of MDR1 may have an influential effect on cytotoxicity of anti-cancer drug and could be available for chemotherapy in clinic. |
| doi_str_mv | 10.4993/acrt.18.13 |
| format | Article |
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Although the substantial evidences that the circadian clock could modulate the morbidity and efficacy of anticancer therapy have been proposed, underlying mechanisms for chronotherapy has been only poorly elucidated, and it has not been popular in clinic. The aim of this study was to determine the relationship between the expression of P-glycoprotein (P-gp)/MDR1, which is one of the important molecules in anti-cancer drug resistance, and circadian rhythm in KB-C2 cells. The present study demonstrated that both MDR1 expression level and its promoter activity oscillated after treatment with high concentration of fetal bovine serum. Moreover, cytotoxic effect of taxol were dependent on the fluctuated levels of MDR1. 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These results suggest that the circadian rhythm of MDR1 may have an influential effect on cytotoxicity of anti-cancer drug and could be available for chemotherapy in clinic.</description><subject>chronotherapy</subject><subject>Circadian Rhythm</subject><subject>MDR1</subject><issn>1344-6835</issn><issn>1880-5469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpFkE9LAzEQxYMoWKsXP0HOwtZks5tNTqKLVrGi-OcckulsTYlZSbYHv71dKvUyM_B-7zE8Qs45m1Vai0sLaZhxNePigEy4UqyoK6kPt7eoqkIqUR-Tk5zXjFWyluWEvL0kzBgBad_R1iewS28j7TP4EOzg-zgKT5sw-GXarOgrZp8HOxrmGJFy6iN9vCnakgKGQIOPeEqOOhsynv3tKfm4u31v74vF8_yhvV4UIGQlCqxL13BsmNYOoGSIzkmQwjmGXEJjrbO1YI0C3QjsSuRYLjvVWATUlqGYkotdLqQ-54Sd-U7-y6Yfw5kZ6zBjHYYrw8UWvtrB6-37K9yjNg0eAv6jf0PsFfi0yWAUv0lbawk</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Sassa, Motoki</creator><creator>Koyama, Yoshihisa</creator><creator>Higashimoto, Masashi</creator><creator>Ono, Koichiro</creator><creator>Yoshimoto, Nobuhiro</creator><creator>Momma, Tomoyuki</creator><creator>Saito, Masaru</creator><creator>Ando, Jin</creator><creator>Noda, Masaru</creator><creator>Miyamoto, Kotaro</creator><creator>Kobayashi, Yusuke</creator><creator>Sugeno, Hidekazu</creator><creator>Ishigame, Teruhide</creator><creator>Fujita, Shotaro</creator><creator>Ito, Testuro</creator><creator>Sakamoto, Wataru</creator><creator>Abe, Noriko</creator><creator>Iwadate, Manabu</creator><creator>Yoshida, Tuneyuki</creator><creator>Ohshima, Takasi</creator><creator>Takebayashi, Yuji</creator><creator>Takenoshita, Seiichi</creator><general>The Japanese Society of Strategies for Cancer Research and Therapy</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2010</creationdate><title>Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line</title><author>Sassa, Motoki ; Koyama, Yoshihisa ; Higashimoto, Masashi ; Ono, Koichiro ; Yoshimoto, Nobuhiro ; Momma, Tomoyuki ; Saito, Masaru ; Ando, Jin ; Noda, Masaru ; Miyamoto, Kotaro ; Kobayashi, Yusuke ; Sugeno, Hidekazu ; Ishigame, Teruhide ; Fujita, Shotaro ; Ito, Testuro ; Sakamoto, Wataru ; Abe, Noriko ; Iwadate, Manabu ; Yoshida, Tuneyuki ; Ohshima, Takasi ; Takebayashi, Yuji ; Takenoshita, Seiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3643-e52b71e7099bcc20eebb6c63bb0e16c7aaba53078c973ef2e1e2df87aece9a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>chronotherapy</topic><topic>Circadian Rhythm</topic><topic>MDR1</topic><toplevel>online_resources</toplevel><creatorcontrib>Sassa, Motoki</creatorcontrib><creatorcontrib>Koyama, Yoshihisa</creatorcontrib><creatorcontrib>Higashimoto, Masashi</creatorcontrib><creatorcontrib>Ono, Koichiro</creatorcontrib><creatorcontrib>Yoshimoto, Nobuhiro</creatorcontrib><creatorcontrib>Momma, Tomoyuki</creatorcontrib><creatorcontrib>Saito, Masaru</creatorcontrib><creatorcontrib>Ando, Jin</creatorcontrib><creatorcontrib>Noda, Masaru</creatorcontrib><creatorcontrib>Miyamoto, Kotaro</creatorcontrib><creatorcontrib>Kobayashi, Yusuke</creatorcontrib><creatorcontrib>Sugeno, Hidekazu</creatorcontrib><creatorcontrib>Ishigame, Teruhide</creatorcontrib><creatorcontrib>Fujita, Shotaro</creatorcontrib><creatorcontrib>Ito, Testuro</creatorcontrib><creatorcontrib>Sakamoto, Wataru</creatorcontrib><creatorcontrib>Abe, Noriko</creatorcontrib><creatorcontrib>Iwadate, Manabu</creatorcontrib><creatorcontrib>Yoshida, Tuneyuki</creatorcontrib><creatorcontrib>Ohshima, Takasi</creatorcontrib><creatorcontrib>Takebayashi, Yuji</creatorcontrib><creatorcontrib>Takenoshita, Seiichi</creatorcontrib><collection>CrossRef</collection><jtitle>Annals of Cancer Research and Therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sassa, Motoki</au><au>Koyama, Yoshihisa</au><au>Higashimoto, Masashi</au><au>Ono, Koichiro</au><au>Yoshimoto, Nobuhiro</au><au>Momma, Tomoyuki</au><au>Saito, Masaru</au><au>Ando, Jin</au><au>Noda, Masaru</au><au>Miyamoto, Kotaro</au><au>Kobayashi, Yusuke</au><au>Sugeno, Hidekazu</au><au>Ishigame, Teruhide</au><au>Fujita, Shotaro</au><au>Ito, Testuro</au><au>Sakamoto, Wataru</au><au>Abe, Noriko</au><au>Iwadate, Manabu</au><au>Yoshida, Tuneyuki</au><au>Ohshima, Takasi</au><au>Takebayashi, Yuji</au><au>Takenoshita, Seiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line</atitle><jtitle>Annals of Cancer Research and Therapy</jtitle><addtitle>Ann. 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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | chronotherapy Circadian Rhythm MDR1 |
| title | Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line |
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