JNK pathway promotes hepatocyte apoptosis by inhibiting Bcl-2 and upregulating expressions of Bim, caspase-3 and caspase-9 after cardiopulmonary bypass

Purpose: To study the effect of Jun N-terminal kinase (JNK) signaling pathway on hepatocyte apoptosis in vivo and in vitro, and to elucidate the mechanism of action. Methods: TdT-mediated dUTP Nick-End Labeling (TUNEL) method was used to determine apoptosis in control and cardiopulmonary bypass (CPB...

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Veröffentlicht in:	Tropical journal of pharmaceutical research 2020-04, Vol.19 (3), p.519-524
Hauptverfasser:	Yu, Haibin, Zhang, Haojie, Cheng, Yan, Fa, Xian’en, Zhu, Fangtao, Lin, Yachao, Huang, Weihua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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