Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles
Purpose: To enhance and control the release of ibuprofen from poly(D,L-lactide-co-glycolide) (PLGA) microparticles. Methods: Ibuprofen-loaded microparticles containing PLGA were formulated using a emulsification/solvent evaporation method. Various concentrations of ibuprofen (200, 300, 400 and 0 mg)...
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| Veröffentlicht in: | Tropical journal of pharmaceutical research 2014-12, Vol.13 (10), p.1571 |
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| container_title | Tropical journal of pharmaceutical research |
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| creator | Momoh, M.A Adedokun, M.O Lawal, S.B Ubochi, G.O |
| description | Purpose: To enhance and control the release of ibuprofen from
poly(D,L-lactide-co-glycolide) (PLGA) microparticles. Methods:
Ibuprofen-loaded microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various concentrations of
ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA
microparticles and the formulations labeled A, B, C and D,
respectively. The microcapsules were characterized for drug loading,
particle size, polydispersity index, zeta potential (ZP) and drug
release. Results: The zeta potential of the microparticles were -53,
-68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively.
Polydispersity index ranged from 0.745 to 0.900. Encapsulation
efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3
and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and
72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve
as an alternative carrier for controlled release of ibuprofen. |
| doi_str_mv | 10.4314/tjpr.v13i10.1 |
| format | Article |
| fullrecord | <record><control><sourceid>bioline_cross</sourceid><recordid>TN_cdi_crossref_primary_10_4314_tjpr_v13i10_1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>cria_bioline_pr_pr14216</sourcerecordid><originalsourceid>FETCH-LOGICAL-b276t-fdc0282b65c872e9be9429fff0b56820e220ec7dc7015882bb932694ec241af93</originalsourceid><addsrcrecordid>eNpFkNFLwzAQxoMoOKePvudRwcwkbdPmUeamg4o-6HNI0kQysqak7WD__TI6FO64u48fd8cHwD3Bizwj-fOw7eJiTzKXBHIBZqTgDPGKlpfnvuCcXYObvt9iXDDOyQyYdYi70cvBhRbKtoGbFu7dEANc7aUfJz1YuFFjF4M1LaqDbEwDv4I_PLw-1chLPbjGIB3Qrz_o4NPwCD-cjqGTcXDam_4WXFnpe3N3rnPws159L99R_fm2Wb7USNGSDcg2GtOKKlboqqSGK8Nzyq21WBWsotjQlLpsdIlJUSVQ8YwynhtNcyItz-YATXvT8b6Pxoouup2MB0GwOHkkTh6JySNBEr-YeOXS3635w3V0UvyLKUhOCcuOGAttuQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles</title><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Momoh, M.A ; Adedokun, M.O ; Lawal, S.B ; Ubochi, G.O</creator><creatorcontrib>Momoh, M.A ; Adedokun, M.O ; Lawal, S.B ; Ubochi, G.O</creatorcontrib><description>Purpose: To enhance and control the release of ibuprofen from
poly(D,L-lactide-co-glycolide) (PLGA) microparticles. Methods:
Ibuprofen-loaded microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various concentrations of
ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA
microparticles and the formulations labeled A, B, C and D,
respectively. The microcapsules were characterized for drug loading,
particle size, polydispersity index, zeta potential (ZP) and drug
release. Results: The zeta potential of the microparticles were -53,
-68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively.
Polydispersity index ranged from 0.745 to 0.900. Encapsulation
efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3
and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and
72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve
as an alternative carrier for controlled release of ibuprofen.</description><identifier>ISSN: 1596-5996</identifier><identifier>EISSN: 1596-9827</identifier><identifier>DOI: 10.4314/tjpr.v13i10.1</identifier><language>eng</language><publisher>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</publisher><subject>Controlled release ; Ibuprofen ; Microparticles ; Polydispersity ; Zeta potential</subject><ispartof>Tropical journal of pharmaceutical research, 2014-12, Vol.13 (10), p.1571</ispartof><rights>Copyright 2014 - Tropical Journal of Pharmaceutical Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b276t-fdc0282b65c872e9be9429fff0b56820e220ec7dc7015882bb932694ec241af93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904,79172</link.rule.ids></links><search><creatorcontrib>Momoh, M.A</creatorcontrib><creatorcontrib>Adedokun, M.O</creatorcontrib><creatorcontrib>Lawal, S.B</creatorcontrib><creatorcontrib>Ubochi, G.O</creatorcontrib><title>Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles</title><title>Tropical journal of pharmaceutical research</title><description>Purpose: To enhance and control the release of ibuprofen from
poly(D,L-lactide-co-glycolide) (PLGA) microparticles. Methods:
Ibuprofen-loaded microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various concentrations of
ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA
microparticles and the formulations labeled A, B, C and D,
respectively. The microcapsules were characterized for drug loading,
particle size, polydispersity index, zeta potential (ZP) and drug
release. Results: The zeta potential of the microparticles were -53,
-68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively.
Polydispersity index ranged from 0.745 to 0.900. Encapsulation
efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3
and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and
72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve
as an alternative carrier for controlled release of ibuprofen.</description><subject>Controlled release</subject><subject>Ibuprofen</subject><subject>Microparticles</subject><subject>Polydispersity</subject><subject>Zeta potential</subject><issn>1596-5996</issn><issn>1596-9827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNpFkNFLwzAQxoMoOKePvudRwcwkbdPmUeamg4o-6HNI0kQysqak7WD__TI6FO64u48fd8cHwD3Bizwj-fOw7eJiTzKXBHIBZqTgDPGKlpfnvuCcXYObvt9iXDDOyQyYdYi70cvBhRbKtoGbFu7dEANc7aUfJz1YuFFjF4M1LaqDbEwDv4I_PLw-1chLPbjGIB3Qrz_o4NPwCD-cjqGTcXDam_4WXFnpe3N3rnPws159L99R_fm2Wb7USNGSDcg2GtOKKlboqqSGK8Nzyq21WBWsotjQlLpsdIlJUSVQ8YwynhtNcyItz-YATXvT8b6Pxoouup2MB0GwOHkkTh6JySNBEr-YeOXS3635w3V0UvyLKUhOCcuOGAttuQ</recordid><startdate>20141209</startdate><enddate>20141209</enddate><creator>Momoh, M.A</creator><creator>Adedokun, M.O</creator><creator>Lawal, S.B</creator><creator>Ubochi, G.O</creator><general>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20141209</creationdate><title>Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles</title><author>Momoh, M.A ; Adedokun, M.O ; Lawal, S.B ; Ubochi, G.O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b276t-fdc0282b65c872e9be9429fff0b56820e220ec7dc7015882bb932694ec241af93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Controlled release</topic><topic>Ibuprofen</topic><topic>Microparticles</topic><topic>Polydispersity</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Momoh, M.A</creatorcontrib><creatorcontrib>Adedokun, M.O</creatorcontrib><creatorcontrib>Lawal, S.B</creatorcontrib><creatorcontrib>Ubochi, G.O</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><jtitle>Tropical journal of pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Momoh, M.A</au><au>Adedokun, M.O</au><au>Lawal, S.B</au><au>Ubochi, G.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles</atitle><jtitle>Tropical journal of pharmaceutical research</jtitle><date>2014-12-09</date><risdate>2014</risdate><volume>13</volume><issue>10</issue><spage>1571</spage><pages>1571-</pages><issn>1596-5996</issn><eissn>1596-9827</eissn><abstract>Purpose: To enhance and control the release of ibuprofen from
poly(D,L-lactide-co-glycolide) (PLGA) microparticles. Methods:
Ibuprofen-loaded microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various concentrations of
ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA
microparticles and the formulations labeled A, B, C and D,
respectively. The microcapsules were characterized for drug loading,
particle size, polydispersity index, zeta potential (ZP) and drug
release. Results: The zeta potential of the microparticles were -53,
-68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively.
Polydispersity index ranged from 0.745 to 0.900. Encapsulation
efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3
and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and
72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve
as an alternative carrier for controlled release of ibuprofen.</abstract><pub>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</pub><doi>10.4314/tjpr.v13i10.1</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1596-5996 |
| ispartof | Tropical journal of pharmaceutical research, 2014-12, Vol.13 (10), p.1571 |
| issn | 1596-5996 1596-9827 |
| language | eng |
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| source | African Journals Online (Open Access); Bioline International; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Controlled release Ibuprofen Microparticles Polydispersity Zeta potential |
| title | Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles |
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