Pathophysiology and Biomarkers in Acute Ischemic Stroke - A Review
Stroke is one of the major causes of death and disability, including ischemic stroke, which accounts for 85 - 87 % of cases. Currently, there are few treatment options available for minimizing tissue death following a stroke. Emerging data suggest that biomarkers may help improve current clinical ou...
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| Veröffentlicht in: | Tropical journal of pharmaceutical research 2013-12, Vol.12 (6), p.1097 |
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| container_issue | 6 |
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| container_title | Tropical journal of pharmaceutical research |
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| creator | Guo, Yiwang Li, Pengyue Guo, Qingli Shang, Kexin Yan, Dan Du, Shouying Lu, Yang |
| description | Stroke is one of the major causes of death and disability, including
ischemic stroke, which accounts for 85 - 87 % of cases. Currently,
there are few treatment options available for minimizing tissue death
following a stroke. Emerging data suggest that biomarkers may help
improve current clinical outcome of stroke. As such, there is a
pressing need to understand the pathophysiology and to explore
effective biomarkers following an ischemic brain event. The
pathophysiology of ischemic stroke is complex, and majorly involves
excitotoxicity, oxidative stress, inflammation, blood-brain barrier
dysfunction, apoptosis, etc. Several of the biomarkers are related to
these pathophysiologic mechanisms and they may have applications in
stroke prediction, diagnosis, assessment, prognosis or treatment. In
this review, we summarized the pathophysiology of ischemic stroke and
some related biomarkers are examined. |
| doi_str_mv | 10.4314/tjpr.v12i6.35 |
| format | Article |
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ischemic stroke, which accounts for 85 - 87 % of cases. Currently,
there are few treatment options available for minimizing tissue death
following a stroke. Emerging data suggest that biomarkers may help
improve current clinical outcome of stroke. As such, there is a
pressing need to understand the pathophysiology and to explore
effective biomarkers following an ischemic brain event. The
pathophysiology of ischemic stroke is complex, and majorly involves
excitotoxicity, oxidative stress, inflammation, blood-brain barrier
dysfunction, apoptosis, etc. Several of the biomarkers are related to
these pathophysiologic mechanisms and they may have applications in
stroke prediction, diagnosis, assessment, prognosis or treatment. In
this review, we summarized the pathophysiology of ischemic stroke and
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ischemic stroke, which accounts for 85 - 87 % of cases. Currently,
there are few treatment options available for minimizing tissue death
following a stroke. Emerging data suggest that biomarkers may help
improve current clinical outcome of stroke. As such, there is a
pressing need to understand the pathophysiology and to explore
effective biomarkers following an ischemic brain event. The
pathophysiology of ischemic stroke is complex, and majorly involves
excitotoxicity, oxidative stress, inflammation, blood-brain barrier
dysfunction, apoptosis, etc. Several of the biomarkers are related to
these pathophysiologic mechanisms and they may have applications in
stroke prediction, diagnosis, assessment, prognosis or treatment. In
this review, we summarized the pathophysiology of ischemic stroke and
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ischemic stroke, which accounts for 85 - 87 % of cases. Currently,
there are few treatment options available for minimizing tissue death
following a stroke. Emerging data suggest that biomarkers may help
improve current clinical outcome of stroke. As such, there is a
pressing need to understand the pathophysiology and to explore
effective biomarkers following an ischemic brain event. The
pathophysiology of ischemic stroke is complex, and majorly involves
excitotoxicity, oxidative stress, inflammation, blood-brain barrier
dysfunction, apoptosis, etc. Several of the biomarkers are related to
these pathophysiologic mechanisms and they may have applications in
stroke prediction, diagnosis, assessment, prognosis or treatment. In
this review, we summarized the pathophysiology of ischemic stroke and
some related biomarkers are examined.</abstract><pub>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</pub><doi>10.4314/tjpr.v12i6.35</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Tropical journal of pharmaceutical research, 2013-12, Vol.12 (6), p.1097 |
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| language | eng |
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| source | African Journals Online (Open Access); Bioline International; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Biomarker Clinical outcomes Ischemic stroke Pathophysiology |
| title | Pathophysiology and Biomarkers in Acute Ischemic Stroke - A Review |
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