Effect of aqueous extract of Irvengia gabonensis on acetaminophen induced Nephrototoxicity in rats

Effect of aqueous extract of Irvengia gabonensis on acetaminophen induced Nephrototoxicity in rats

The use of medicinal plant to prevent and/or cure liver problems is a practice not peculiar to developing countries. This research work evaluated the nephrocurative ability of aqueous seed extract of Irvengia gabonensis on Acetaminophen Induced Nephrotoxicity. A total of thirty albino rats were grou...

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Veröffentlicht in:Bayero journal of pure and applied sciences 2021-12, Vol.14 (1), p.13-16
Hauptverfasser: Muhammad, I.U., Idi, A., Ibrahim, A.B., Abubakar, B.M.
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description The use of medicinal plant to prevent and/or cure liver problems is a practice not peculiar to developing countries. This research work evaluated the nephrocurative ability of aqueous seed extract of Irvengia gabonensis on Acetaminophen Induced Nephrotoxicity. A total of thirty albino rats were grouped into six groups (GI – GVI) of five rats each. GI served as normal control, GII served as positive control, GIII, GIV and GV were administered with the extract at a dose of 50mg/Kg, 100mg/Kg and 150mg/Kg respectively while GVI rats were administered with standard drug (Vit E) at a dose of 10mg/Kg. Kidney damage was induced in groups (II-VI) using 800mg/Kg of acetaminophen administered orally, rats from group I and II were euthanized24 hours after acetaminophen administration to confirm inducement of kidney damage. Groups III, IV, V and VI were administered with the respective doses for two weeks. A significant decrease (p
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A significant decrease (p&lt;0.05) in mean serum level of Urea, Potassium (K+), Chloride (Clˉ) and Creatinine with a significant increase (p&lt;0.05) in the level of serum Sodium (Na+) and Bicarbonate (HCO3ˉ) was observed when compared with positive control. 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title Effect of aqueous extract of Irvengia gabonensis on acetaminophen induced Nephrototoxicity in rats
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