(4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA
The dichloromethane extract of Securidaca longepedunculata Fresen yielded a benzophenone, (4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl 2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoa...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2006-01, Vol.3 (3) |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H |
| description | The dichloromethane extract of Securidaca longepedunculata Fresen
yielded a benzophenone,
(4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with
otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl
2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate
(4). Compound (1) exhibited antibacterial activity against Pseudomonas
aeruginosa , and antifungal activity against Aspergillus fumigatus .
Compound 2 exhibited antibacterial activity against Staphylococcus
aureus , and antifungal activity against Aspergillus niger ,
Aspergillus fumigatus and a Penicillum species. Compounds 3 and 4
were inactive against all the tested bacteria and fungi. These results
provide proof of efficacy of the extracts of S.longepedunculata in
treating bacterial infections, but further studies should be carried
out to ascertain these results with respect to the widely reported
traditional use. |
| doi_str_mv | 10.4314/ajtcam.v3i3.31169 |
| format | Article |
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yielded a benzophenone,
(4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with
otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl
2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate
(4). Compound (1) exhibited antibacterial activity against Pseudomonas
aeruginosa , and antifungal activity against Aspergillus fumigatus .
Compound 2 exhibited antibacterial activity against Staphylococcus
aureus , and antifungal activity against Aspergillus niger ,
Aspergillus fumigatus and a Penicillum species. Compounds 3 and 4
were inactive against all the tested bacteria and fungi. These results
provide proof of efficacy of the extracts of S.longepedunculata in
treating bacterial infections, but further studies should be carried
out to ascertain these results with respect to the widely reported
traditional use.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 0189-6016</identifier><identifier>DOI: 10.4314/ajtcam.v3i3.31169</identifier><language>eng</language><publisher>African Ethnomedicines Network</publisher><subject>Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2006-01, Vol.3 (3)</ispartof><rights>Copyright 2006 - African Journal Traditional, Complementary and Alternative Medicines</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b284t-41167a9609fd14cdc3b39b375becdc42066d9ae30349e6e5b19915c44af65d493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79426</link.rule.ids></links><search><creatorcontrib>Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H</creatorcontrib><title>(4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA</title><title>African journal of traditional, complementary, and alternative medicines</title><description>The dichloromethane extract of Securidaca longepedunculata Fresen
yielded a benzophenone,
(4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with
otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl
2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate
(4). Compound (1) exhibited antibacterial activity against Pseudomonas
aeruginosa , and antifungal activity against Aspergillus fumigatus .
Compound 2 exhibited antibacterial activity against Staphylococcus
aureus , and antifungal activity against Aspergillus niger ,
Aspergillus fumigatus and a Penicillum species. Compounds 3 and 4
were inactive against all the tested bacteria and fungi. These results
provide proof of efficacy of the extracts of S.longepedunculata in
treating bacterial infections, but further studies should be carried
out to ascertain these results with respect to the widely reported
traditional use.</description><subject>Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone</subject><issn>0189-6016</issn><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNpNkF1LwzAUhoMoOKc_wLteKpiaLGm2eJd12VbImjFb2BQpaZtCxz60HYL_3nZTEV44n8-B8wJwi5FLCaaPZn3IzNb9JCVxCcaMn4EOwgMOGcLs_F9-Ca7qeo0QGeBevwM-7iicyWiqlys4lOGLfsUP5G0U6KVW0IMrdQ_nUxmuVLskQh3KJ0eEjaJgKPxILgKhnCPYrjVjZ7zQM-dZ-vEiGAlfOEqHEzmXozj0YyUicQ0uCrOp7c1P7IJ4LCN_CpWeBL5QMO0N6AHS5om-4QzxIsc0yzOSEp6SvpfapqA9xFjOjSWIUG6Z9VLMOfYySk3BvJxy0gX4dDer9nVd2SJ5r8qtqb4SjJLWs-TkWdJ6lhw9axj3xKTlflPu7B-SVaVJfpuHrBFiiCLyDWOLaZ4</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H</creator><general>African Ethnomedicines Network</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20060101</creationdate><title>(4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA</title><author>Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b284t-41167a9609fd14cdc3b39b375becdc42066d9ae30349e6e5b19915c44af65d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><date>2006-01-01</date><risdate>2006</risdate><volume>3</volume><issue>3</issue><issn>0189-6016</issn><eissn>0189-6016</eissn><abstract>The dichloromethane extract of Securidaca longepedunculata Fresen
yielded a benzophenone,
(4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with
otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl
2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate
(4). Compound (1) exhibited antibacterial activity against Pseudomonas
aeruginosa , and antifungal activity against Aspergillus fumigatus .
Compound 2 exhibited antibacterial activity against Staphylococcus
aureus , and antifungal activity against Aspergillus niger ,
Aspergillus fumigatus and a Penicillum species. Compounds 3 and 4
were inactive against all the tested bacteria and fungi. These results
provide proof of efficacy of the extracts of S.longepedunculata in
treating bacterial infections, but further studies should be carried
out to ascertain these results with respect to the widely reported
traditional use.</abstract><pub>African Ethnomedicines Network</pub><doi>10.4314/ajtcam.v3i3.31169</doi></addata></record> |
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| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2006-01, Vol.3 (3) |
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| language | eng |
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| source | Bioline International |
| subjects | Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone |
| title | (4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA |
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