Chemical constituents and Antimicrobial activity of A Traditional Herbal Medicine Containing Garlic and Black Cumin
A combination of crushed garlic ( Allium sativum ) and black cumin seeds ( Nigelia sativum ) has been used as a traditional remedy for urinary tract infections. In-vitro antimicrobial testing suggested that the mixture of two spices in the ratio of 1:1 has antimicrobial effects on both Staphylococcu...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2006-08, Vol.3 (2) |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas |
| description | A combination of crushed garlic ( Allium sativum ) and black cumin
seeds ( Nigelia sativum ) has been used as a traditional remedy for
urinary tract infections. In-vitro antimicrobial testing suggested that
the mixture of two spices in the ratio of 1:1 has antimicrobial effects
on both Staphylococcus aureus and Escherichia coli species.
Analyses of the extract of garlic and black cumin by GC-MS as well as
LC-MS & MS2 confirmed that the main components of garlic were
allicin, γ-glutamyl-S-allylcysteine and allicin transformed
products such as diallyldisulfide and vinyldithiins. Components of
black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and
pinene. Isolated samples of allicin by preparative HPLC from garlic
extract and reference samples of diallyldisulfide and thymoquinone were
tested individually and in combination for their antimicrobial
activities against S. aureus and E. coli. All of these compounds showed
modest antimicrobial effects individually (except diallyldisulfide
against E. coli) and in combination. |
| doi_str_mv | 10.4314/ajtcam.v3i2.31151 |
| format | Article |
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seeds ( Nigelia sativum ) has been used as a traditional remedy for
urinary tract infections. In-vitro antimicrobial testing suggested that
the mixture of two spices in the ratio of 1:1 has antimicrobial effects
on both Staphylococcus aureus and Escherichia coli species.
Analyses of the extract of garlic and black cumin by GC-MS as well as
LC-MS & MS2 confirmed that the main components of garlic were
allicin, γ-glutamyl-S-allylcysteine and allicin transformed
products such as diallyldisulfide and vinyldithiins. Components of
black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and
pinene. Isolated samples of allicin by preparative HPLC from garlic
extract and reference samples of diallyldisulfide and thymoquinone were
tested individually and in combination for their antimicrobial
activities against S. aureus and E. coli. All of these compounds showed
modest antimicrobial effects individually (except diallyldisulfide
against E. coli) and in combination.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 0189-6016</identifier><identifier>DOI: 10.4314/ajtcam.v3i2.31151</identifier><language>eng</language><publisher>African Ethnomedicines Network</publisher><subject>Garlic, Black cumin, Diallyldisulfide, Thymoquinone, Antimicrobial activity</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2006-08, Vol.3 (2)</ispartof><rights>Copyright 2006 - African Journal Traditional, Complementary and Alternative Medicines</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b2421-aae8878623ca12ec29297c89802dbe3b0e9fbb9e57eec1e591ce0b52ffce5ac93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904,79172</link.rule.ids></links><search><creatorcontrib>Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas</creatorcontrib><title>Chemical constituents and Antimicrobial activity of A Traditional Herbal Medicine Containing Garlic and Black Cumin</title><title>African journal of traditional, complementary, and alternative medicines</title><description>A combination of crushed garlic ( Allium sativum ) and black cumin
seeds ( Nigelia sativum ) has been used as a traditional remedy for
urinary tract infections. In-vitro antimicrobial testing suggested that
the mixture of two spices in the ratio of 1:1 has antimicrobial effects
on both Staphylococcus aureus and Escherichia coli species.
Analyses of the extract of garlic and black cumin by GC-MS as well as
LC-MS & MS2 confirmed that the main components of garlic were
allicin, γ-glutamyl-S-allylcysteine and allicin transformed
products such as diallyldisulfide and vinyldithiins. Components of
black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and
pinene. Isolated samples of allicin by preparative HPLC from garlic
extract and reference samples of diallyldisulfide and thymoquinone were
tested individually and in combination for their antimicrobial
activities against S. aureus and E. coli. All of these compounds showed
modest antimicrobial effects individually (except diallyldisulfide
against E. coli) and in combination.</description><subject>Garlic, Black cumin, Diallyldisulfide, Thymoquinone, Antimicrobial activity</subject><issn>0189-6016</issn><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNpNkN1KAzEQhYMoWKsP4F1eYNf8dH9yWRe1QsWber0k2Vmdus1Kkhb69qatijBwhjmcgfMRcstZPpN8dqfX0epNvpMocsl5wc_IhPFaZSXj5fm__ZJchbBmTNZcVBMSmg_YoNUDtaMLEeMWXAxUu47OXcRk-dFgsrWNuMO4p2NP53TldYcRR5ecBXiT5AU6tOiANqOLGh26d_qk_YD2-O1-0PaTNtsNumty0eshwM2PTsnb48OqWWTL16fnZr7MjJgJnmkNdV3VpZBWcwFWKKEqW6uaic6ANAxUb4yCogKwHArFLTBTiL63UGir5JTw09_UIQQPffvlcaP9vuWsPVBrT9TaA7X2SC1l8lPG4DikNn8R61G3v8do07CSSSa_Aes1dfo</recordid><startdate>20060821</startdate><enddate>20060821</enddate><creator>Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas</creator><general>African Ethnomedicines Network</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20060821</creationdate><title>Chemical constituents and Antimicrobial activity of A Traditional Herbal Medicine Containing Garlic and Black Cumin</title><author>Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2421-aae8878623ca12ec29297c89802dbe3b0e9fbb9e57eec1e591ce0b52ffce5ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Garlic, Black cumin, Diallyldisulfide, Thymoquinone, Antimicrobial activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiben Roy, Diaa M. Shakleya, Patrick S. Callery and John G. Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical constituents and Antimicrobial activity of A Traditional Herbal Medicine Containing Garlic and Black Cumin</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><date>2006-08-21</date><risdate>2006</risdate><volume>3</volume><issue>2</issue><issn>0189-6016</issn><eissn>0189-6016</eissn><abstract>A combination of crushed garlic ( Allium sativum ) and black cumin
seeds ( Nigelia sativum ) has been used as a traditional remedy for
urinary tract infections. In-vitro antimicrobial testing suggested that
the mixture of two spices in the ratio of 1:1 has antimicrobial effects
on both Staphylococcus aureus and Escherichia coli species.
Analyses of the extract of garlic and black cumin by GC-MS as well as
LC-MS & MS2 confirmed that the main components of garlic were
allicin, γ-glutamyl-S-allylcysteine and allicin transformed
products such as diallyldisulfide and vinyldithiins. Components of
black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and
pinene. Isolated samples of allicin by preparative HPLC from garlic
extract and reference samples of diallyldisulfide and thymoquinone were
tested individually and in combination for their antimicrobial
activities against S. aureus and E. coli. All of these compounds showed
modest antimicrobial effects individually (except diallyldisulfide
against E. coli) and in combination.</abstract><pub>African Ethnomedicines Network</pub><doi>10.4314/ajtcam.v3i2.31151</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2006-08, Vol.3 (2) |
| issn | 0189-6016 0189-6016 |
| language | eng |
| recordid | cdi_crossref_primary_10_4314_ajtcam_v3i2_31151 |
| source | Bioline International |
| subjects | Garlic, Black cumin, Diallyldisulfide, Thymoquinone, Antimicrobial activity |
| title | Chemical constituents and Antimicrobial activity of A Traditional Herbal Medicine Containing Garlic and Black Cumin |
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