Might the fungus Candida albicans be a risk factor for autism? A meta-analysis study

Might the fungus Candida albicans be a risk factor for autism? A meta-analysis study

Objective: Due to the high increase in rate of autism, it has gained great importance to determine the etiology of autism spectrumdisorder. The purpose of our study was to assess the role of Candida albicans as a risk factor to cause autism behavior.Methods: We searched Scopus, PubMed, Web of Scienc...

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Veröffentlicht in:African health sciences 2023-12, Vol.23 (4), p.230-235
Hauptverfasser: Emrah Gokay, Ozgur, Sibel, Balci
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description Objective: Due to the high increase in rate of autism, it has gained great importance to determine the etiology of autism spectrumdisorder. The purpose of our study was to assess the role of Candida albicans as a risk factor to cause autism behavior.Methods: We searched Scopus, PubMed, Web of Science and PsycINFO for articles up to December, 2021. The studies involving children diagnosed with autism spectrum disorder were included. Children’ outcomes were selected as Candida albicans (positive) and Candida albicans (negative). Odds ratios were reported using fixed-effect and random-effect meta-analysis. The heterogeneity was assessed by the Chi-square test and Higgins' I2 test. The publication bias was examined via funnel plot and Hegger’s test.Results: Our meta-analysis was conducted based on 254 diagnosed with Autism Spectrum Disease cases and 161 healthy cases from 4 studies. Compared to the healthy cases, the odds of presence of Candida albicans (OR=7.21; 95% CI: 3.75-13.85; p
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A meta-analysis study</title><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Emrah Gokay, Ozgur ; Sibel, Balci</creator><creatorcontrib>Emrah Gokay, Ozgur ; Sibel, Balci</creatorcontrib><description>Objective: Due to the high increase in rate of autism, it has gained great importance to determine the etiology of autism spectrumdisorder. The purpose of our study was to assess the role of Candida albicans as a risk factor to cause autism behavior.Methods: We searched Scopus, PubMed, Web of Science and PsycINFO for articles up to December, 2021. The studies involving children diagnosed with autism spectrum disorder were included. Children’ outcomes were selected as Candida albicans (positive) and Candida albicans (negative). Odds ratios were reported using fixed-effect and random-effect meta-analysis. The heterogeneity was assessed by the Chi-square test and Higgins' I2 test. The publication bias was examined via funnel plot and Hegger’s test.Results: Our meta-analysis was conducted based on 254 diagnosed with Autism Spectrum Disease cases and 161 healthy cases from 4 studies. Compared to the healthy cases, the odds of presence of Candida albicans (OR=7.21; 95% CI: 3.75-13.85; p&lt;0.001) were higher in those diagnosed with autism spectrum disorder.Conclusion: This study as a whole showed that children diagnosed with autism spectrum disorder have higher frequency of the presence of the fungus Candida albicans. Therefore, Candida albicans may be an etiological factor for the autistic behavior in children.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>DOI: 10.4314/ahs.v23i4.25</identifier><language>eng</language><ispartof>African health sciences, 2023-12, Vol.23 (4), p.230-235</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Emrah Gokay, Ozgur</creatorcontrib><creatorcontrib>Sibel, Balci</creatorcontrib><title>Might the fungus Candida albicans be a risk factor for autism? A meta-analysis study</title><title>African health sciences</title><description>Objective: Due to the high increase in rate of autism, it has gained great importance to determine the etiology of autism spectrumdisorder. The purpose of our study was to assess the role of Candida albicans as a risk factor to cause autism behavior.Methods: We searched Scopus, PubMed, Web of Science and PsycINFO for articles up to December, 2021. The studies involving children diagnosed with autism spectrum disorder were included. Children’ outcomes were selected as Candida albicans (positive) and Candida albicans (negative). Odds ratios were reported using fixed-effect and random-effect meta-analysis. The heterogeneity was assessed by the Chi-square test and Higgins' I2 test. The publication bias was examined via funnel plot and Hegger’s test.Results: Our meta-analysis was conducted based on 254 diagnosed with Autism Spectrum Disease cases and 161 healthy cases from 4 studies. Compared to the healthy cases, the odds of presence of Candida albicans (OR=7.21; 95% CI: 3.75-13.85; p&lt;0.001) were higher in those diagnosed with autism spectrum disorder.Conclusion: This study as a whole showed that children diagnosed with autism spectrum disorder have higher frequency of the presence of the fungus Candida albicans. 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A meta-analysis study</title><author>Emrah Gokay, Ozgur ; Sibel, Balci</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c755-32af0fa97c7d01432779689cdbb5922e750ea591eeeee1029cceea1ec1f35bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emrah Gokay, Ozgur</creatorcontrib><creatorcontrib>Sibel, Balci</creatorcontrib><collection>CrossRef</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emrah Gokay, Ozgur</au><au>Sibel, Balci</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Might the fungus Candida albicans be a risk factor for autism? A meta-analysis study</atitle><jtitle>African health sciences</jtitle><date>2023-12-27</date><risdate>2023</risdate><volume>23</volume><issue>4</issue><spage>230</spage><epage>235</epage><pages>230-235</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><abstract>Objective: Due to the high increase in rate of autism, it has gained great importance to determine the etiology of autism spectrumdisorder. The purpose of our study was to assess the role of Candida albicans as a risk factor to cause autism behavior.Methods: We searched Scopus, PubMed, Web of Science and PsycINFO for articles up to December, 2021. The studies involving children diagnosed with autism spectrum disorder were included. Children’ outcomes were selected as Candida albicans (positive) and Candida albicans (negative). Odds ratios were reported using fixed-effect and random-effect meta-analysis. The heterogeneity was assessed by the Chi-square test and Higgins' I2 test. The publication bias was examined via funnel plot and Hegger’s test.Results: Our meta-analysis was conducted based on 254 diagnosed with Autism Spectrum Disease cases and 161 healthy cases from 4 studies. Compared to the healthy cases, the odds of presence of Candida albicans (OR=7.21; 95% CI: 3.75-13.85; p&lt;0.001) were higher in those diagnosed with autism spectrum disorder.Conclusion: This study as a whole showed that children diagnosed with autism spectrum disorder have higher frequency of the presence of the fungus Candida albicans. Therefore, Candida albicans may be an etiological factor for the autistic behavior in children.</abstract><doi>10.4314/ahs.v23i4.25</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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title Might the fungus Candida albicans be a risk factor for autism? A meta-analysis study
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