Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting

The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziq...

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Veröffentlicht in:The American journal of tropical medicine and hygiene 2020-07, Vol.103 (1), p.105-113
Hauptverfasser: Binder, Sue, Campbell, Carl H., Castleman, Jennifer D., Kittur, Nupur, Kinung'hi, Safari M., Olsen, Annette, Magnussen, Pascal, Karanja, Diana M. S., Mwinzi, Pauline N. M., Montgomery, Susan P., Secor, William Evan, Phillips, Anna E., Dhanani, Neerav, Gazzinelli-Guimaraes, Pedro H., Clements, Michelle N., N'Goran, Eliezer K., Meite, Aboulaye, Utzinger, Jurg, Hamidou, Amina A., Garba, Amadou, Fleming, Fiona M., Whalen, Christopher C., King, Charles H., Colley, Daniel G.
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container_issue 1
container_start_page 105
container_title The American journal of tropical medicine and hygiene
container_volume 103
creator Binder, Sue
Campbell, Carl H.
Castleman, Jennifer D.
Kittur, Nupur
Kinung'hi, Safari M.
Olsen, Annette
Magnussen, Pascal
Karanja, Diana M. S.
Mwinzi, Pauline N. M.
Montgomery, Susan P.
Secor, William Evan
Phillips, Anna E.
Dhanani, Neerav
Gazzinelli-Guimaraes, Pedro H.
Clements, Michelle N.
N'Goran, Eliezer K.
Meite, Aboulaye
Utzinger, Jurg
Hamidou, Amina A.
Garba, Amadou
Fleming, Fiona M.
Whalen, Christopher C.
King, Charles H.
Colley, Daniel G.
description The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziquantel. The largest of these were studies of gaining or sustaining control of schistosomiasis, which were conducted in five African countries. To enhance relevance for routine practice, the MDA in these studies was coordinated by or closely aligned with national neglected tropical disease (NTD) control programs. The study protocol set minimum targets of at least 90% for coverage among children enrolled in schools and 75% for all school-age children. Over the 4 years of intervention, an estimated 3.5 million treatments were administered to study communities. By year 4, the median village coverage was at or above targets in all studies except that in Mozambique. However, there was often a wide variation behind these summary statistics, and all studies had several villages with very low or high coverage. In studies where coverage was estimated by comparing the number of people treated with the number eligible for treatment, denominator estimation was often problematic. The SCORE experiences in conducting these studies provide lessons for future efforts that attempt to implement strong research designs in real-world contexts. They also have potential applicability to country MDA campaigns against schistosomiasis and other NTDs, most of which are conducted with less logistical and financial support than was available for the SCORE study efforts.
doi_str_mv 10.4269/ajtmh.19-0789
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source MEDLINE; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection
subjects Africa
Animals
Anthelmintics - therapeutic use
Child
Child, Preschool
Female
Humans
Life Sciences & Biomedicine
Male
Mass Drug Administration
Mozambique
Neglected Diseases - drug therapy
Neglected Diseases - prevention & control
Praziquantel - therapeutic use
Prevalence
Public Health
Public, Environmental & Occupational Health
Rural Population
Schistosoma
Schistosomiasis - drug therapy
Schistosomiasis - prevention & control
Schools
Science & Technology
Tropical diseases
Tropical Medicine
title Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting
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