Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziq...
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creator | Binder, Sue Campbell, Carl H. Castleman, Jennifer D. Kittur, Nupur Kinung'hi, Safari M. Olsen, Annette Magnussen, Pascal Karanja, Diana M. S. Mwinzi, Pauline N. M. Montgomery, Susan P. Secor, William Evan Phillips, Anna E. Dhanani, Neerav Gazzinelli-Guimaraes, Pedro H. Clements, Michelle N. N'Goran, Eliezer K. Meite, Aboulaye Utzinger, Jurg Hamidou, Amina A. Garba, Amadou Fleming, Fiona M. Whalen, Christopher C. King, Charles H. Colley, Daniel G. |
description | The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziquantel. The largest of these were studies of gaining or sustaining control of schistosomiasis, which were conducted in five African countries. To enhance relevance for routine practice, the MDA in these studies was coordinated by or closely aligned with national neglected tropical disease (NTD) control programs. The study protocol set minimum targets of at least 90% for coverage among children enrolled in schools and 75% for all school-age children. Over the 4 years of intervention, an estimated 3.5 million treatments were administered to study communities. By year 4, the median village coverage was at or above targets in all studies except that in Mozambique. However, there was often a wide variation behind these summary statistics, and all studies had several villages with very low or high coverage. In studies where coverage was estimated by comparing the number of people treated with the number eligible for treatment, denominator estimation was often problematic. The SCORE experiences in conducting these studies provide lessons for future efforts that attempt to implement strong research designs in real-world contexts. They also have potential applicability to country MDA campaigns against schistosomiasis and other NTDs, most of which are conducted with less logistical and financial support than was available for the SCORE study efforts. |
doi_str_mv | 10.4269/ajtmh.19-0789 |
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M. ; Montgomery, Susan P. ; Secor, William Evan ; Phillips, Anna E. ; Dhanani, Neerav ; Gazzinelli-Guimaraes, Pedro H. ; Clements, Michelle N. ; N'Goran, Eliezer K. ; Meite, Aboulaye ; Utzinger, Jurg ; Hamidou, Amina A. ; Garba, Amadou ; Fleming, Fiona M. ; Whalen, Christopher C. ; King, Charles H. ; Colley, Daniel G.</creatorcontrib><description>The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziquantel. The largest of these were studies of gaining or sustaining control of schistosomiasis, which were conducted in five African countries. To enhance relevance for routine practice, the MDA in these studies was coordinated by or closely aligned with national neglected tropical disease (NTD) control programs. The study protocol set minimum targets of at least 90% for coverage among children enrolled in schools and 75% for all school-age children. Over the 4 years of intervention, an estimated 3.5 million treatments were administered to study communities. By year 4, the median village coverage was at or above targets in all studies except that in Mozambique. However, there was often a wide variation behind these summary statistics, and all studies had several villages with very low or high coverage. In studies where coverage was estimated by comparing the number of people treated with the number eligible for treatment, denominator estimation was often problematic. The SCORE experiences in conducting these studies provide lessons for future efforts that attempt to implement strong research designs in real-world contexts. 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S.</creatorcontrib><creatorcontrib>Mwinzi, Pauline N. M.</creatorcontrib><creatorcontrib>Montgomery, Susan P.</creatorcontrib><creatorcontrib>Secor, William Evan</creatorcontrib><creatorcontrib>Phillips, Anna E.</creatorcontrib><creatorcontrib>Dhanani, Neerav</creatorcontrib><creatorcontrib>Gazzinelli-Guimaraes, Pedro H.</creatorcontrib><creatorcontrib>Clements, Michelle N.</creatorcontrib><creatorcontrib>N'Goran, Eliezer K.</creatorcontrib><creatorcontrib>Meite, Aboulaye</creatorcontrib><creatorcontrib>Utzinger, Jurg</creatorcontrib><creatorcontrib>Hamidou, Amina A.</creatorcontrib><creatorcontrib>Garba, Amadou</creatorcontrib><creatorcontrib>Fleming, Fiona M.</creatorcontrib><creatorcontrib>Whalen, Christopher C.</creatorcontrib><creatorcontrib>King, Charles H.</creatorcontrib><creatorcontrib>Colley, Daniel G.</creatorcontrib><title>Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting</title><title>The American journal of tropical medicine and hygiene</title><addtitle>AM J TROP MED HYG</addtitle><addtitle>Am J Trop Med Hyg</addtitle><description>The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. 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subjects | Africa Animals Anthelmintics - therapeutic use Child Child, Preschool Female Humans Life Sciences & Biomedicine Male Mass Drug Administration Mozambique Neglected Diseases - drug therapy Neglected Diseases - prevention & control Praziquantel - therapeutic use Prevalence Public Health Public, Environmental & Occupational Health Rural Population Schistosoma Schistosomiasis - drug therapy Schistosomiasis - prevention & control Schools Science & Technology Tropical diseases Tropical Medicine |
title | Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting |
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