Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permi...

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Veröffentlicht in:	RNA biology 2013-08, Vol.10 (8), p.1333-1344
Hauptverfasser:	Li, Cheryl CY, Eaton, Sally A, Young, Paul E, Lee, Maggie, Shuttleworth, Rupert, Humphreys, David T, Grau, Georges E, Combes, Valery, Bebawy, Mary, Gong, Joyce, Brammah, Susan, Buckland, Michael E, Suter, Catherine M
Format:	Artikel
Sprache:	eng
Schlagworte:	acute exposure brain brain neoplasms Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Endothelial Cells - metabolism Endothelial Cells - pathology exosome Exosomes - genetics Exosomes - metabolism gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic glioblastoma glioma Glioma - metabolism Glioma - physiopathology Humans microparticle microRNA Microvessels - cytology Neovascularization, Pathologic Research Paper RNA Transport RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism RNA, Untranslated - metabolism small noncoding RNA vault RNA
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