Chromosomes without a 30-nm chromatin fiber

How is a long strand of genomic DNA packaged into a mitotic chromosome or nucleus? The nucleosome fiber (beads-on-a-string), in which DNA is wrapped around core histones, has long been assumed to be folded into a 30-nm chromatin fiber, and a further helically folded larger fiber. However, when froze...

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Veröffentlicht in:	Nucleus (Austin, Tex.) Tex.), 2012-09, Vol.3 (5), p.404-410
Hauptverfasser:	Joti, Yasumasa, Hikima, Takaaki, Nishino, Yoshinori, Kamada, Fukumi, Hihara, Saera, Takata, Hideaki, Ishikawa, Tetsuya, Maeshima, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	30-nm chromatin fiber Binding Biology Bioscience Calcium Cancer Cell Cell Nucleus - metabolism chromatin Chromatin - chemistry Chromatin - metabolism Chromosome Structures - chemistry Chromosome Structures - metabolism cryo-electron microscopy cryo-EM Cycle DNA Extra View fractal nature HeLa Cells histones Histones - chemistry Histones - metabolism Humans Interphase interphase nuclei irregular folding Landes Mitosis mitotic chromosomes nucleosomes Nucleosomes - chemistry Nucleosomes - metabolism Organogenesis Proteins Scattering, Small Angle small-angle X-ray scattering X-Ray Diffraction X-ray scattering
Online-Zugang:	Volltext
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