Multiple roles for Hox genes in segment-specific shaping of CNS lineages
In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing...
Gespeichert in:
| Veröffentlicht in: | Fly (Austin, Tex.) Tex.), 2008-11, Vol.2 (6), p.316-319 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 319 |
|---|---|
| container_issue | 6 |
| container_start_page | 316 |
| container_title | Fly (Austin, Tex.) |
| container_volume | 2 |
| creator | Rogulja-Ortmann, Ana Technau, Gerhard M. |
| description | In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns. |
| doi_str_mv | 10.4161/fly.7464 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_4161_fly_7464</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66661942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-d742c8426bae29b91f0917732a3e4b6efdffb34ecb8e2d42d11d1579396765c3</originalsourceid><addsrcrecordid>eNplkE1PxCAQhonRuH4l_gLDyXiplkLBHs1GXRM_DnonlA4rhkKFbnT_vWx2XQ_OhSF5eGd4EDol5SUjnFwZt7wUjLMddEAaSgvesGp321M2QYcpfZRlLeqy3kcT0pRC1Kw6QLOnhRvt4ADH4CBhEyKehW88B59v1uME8x78WKQBtDVW4_SuBuvnOBg8fX7FznpQc0jHaM8ol-Bkcx6ht7vbt-mseHy5f5jePBaacj4WnWCVvmYVbxVUTdsQUzZECFopCqzlYDpjWspAt9dQdazqCOlILRracMFrTY_Q-Tp2iOFzAWmUvU0anFMewiJJnovk32fwYg3qGFKKYOQQba_iUpJSrqTJLE2upGX0bJO5aHvo_sCNpQyUayBP6SC1NiRtwWvYoqssFUerHfxm0vUT67PSXn2F6Do5qqUL0UTltU2S_tvkB-reiyU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66661942</pqid></control><display><type>article</type><title>Multiple roles for Hox genes in segment-specific shaping of CNS lineages</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Rogulja-Ortmann, Ana ; Technau, Gerhard M.</creator><creatorcontrib>Rogulja-Ortmann, Ana ; Technau, Gerhard M.</creatorcontrib><description>In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns.</description><identifier>ISSN: 1933-6934</identifier><identifier>EISSN: 1933-6942</identifier><identifier>DOI: 10.4161/fly.7464</identifier><identifier>PMID: 19077542</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Apoptosis ; Binding ; Biology ; Bioscience ; Calcium ; Cancer ; Cell ; Cell Differentiation ; Cell Proliferation ; Central Nervous System - cytology ; Central Nervous System - embryology ; Cycle ; Drosophila melanogaster - cytology ; Drosophila melanogaster - embryology ; Drosophila melanogaster - physiology ; Genes, Homeobox - physiology ; Landes ; Organogenesis ; Proteins</subject><ispartof>Fly (Austin, Tex.), 2008-11, Vol.2 (6), p.316-319</ispartof><rights>Copyright © 2008 Landes Bioscience 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-d742c8426bae29b91f0917732a3e4b6efdffb34ecb8e2d42d11d1579396765c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19077542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rogulja-Ortmann, Ana</creatorcontrib><creatorcontrib>Technau, Gerhard M.</creatorcontrib><title>Multiple roles for Hox genes in segment-specific shaping of CNS lineages</title><title>Fly (Austin, Tex.)</title><addtitle>Fly (Austin)</addtitle><description>In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Central Nervous System - cytology</subject><subject>Central Nervous System - embryology</subject><subject>Cycle</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - physiology</subject><subject>Genes, Homeobox - physiology</subject><subject>Landes</subject><subject>Organogenesis</subject><subject>Proteins</subject><issn>1933-6934</issn><issn>1933-6942</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNplkE1PxCAQhonRuH4l_gLDyXiplkLBHs1GXRM_DnonlA4rhkKFbnT_vWx2XQ_OhSF5eGd4EDol5SUjnFwZt7wUjLMddEAaSgvesGp321M2QYcpfZRlLeqy3kcT0pRC1Kw6QLOnhRvt4ADH4CBhEyKehW88B59v1uME8x78WKQBtDVW4_SuBuvnOBg8fX7FznpQc0jHaM8ol-Bkcx6ht7vbt-mseHy5f5jePBaacj4WnWCVvmYVbxVUTdsQUzZECFopCqzlYDpjWspAt9dQdazqCOlILRracMFrTY_Q-Tp2iOFzAWmUvU0anFMewiJJnovk32fwYg3qGFKKYOQQba_iUpJSrqTJLE2upGX0bJO5aHvo_sCNpQyUayBP6SC1NiRtwWvYoqssFUerHfxm0vUT67PSXn2F6Do5qqUL0UTltU2S_tvkB-reiyU</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Rogulja-Ortmann, Ana</creator><creator>Technau, Gerhard M.</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Multiple roles for Hox genes in segment-specific shaping of CNS lineages</title><author>Rogulja-Ortmann, Ana ; Technau, Gerhard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-d742c8426bae29b91f0917732a3e4b6efdffb34ecb8e2d42d11d1579396765c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Central Nervous System - cytology</topic><topic>Central Nervous System - embryology</topic><topic>Cycle</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - physiology</topic><topic>Genes, Homeobox - physiology</topic><topic>Landes</topic><topic>Organogenesis</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogulja-Ortmann, Ana</creatorcontrib><creatorcontrib>Technau, Gerhard M.</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fly (Austin, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogulja-Ortmann, Ana</au><au>Technau, Gerhard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple roles for Hox genes in segment-specific shaping of CNS lineages</atitle><jtitle>Fly (Austin, Tex.)</jtitle><addtitle>Fly (Austin)</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>2</volume><issue>6</issue><spage>316</spage><epage>319</epage><pages>316-319</pages><issn>1933-6934</issn><eissn>1933-6942</eissn><abstract>In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>19077542</pmid><doi>10.4161/fly.7464</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1933-6934 |
| ispartof | Fly (Austin, Tex.), 2008-11, Vol.2 (6), p.316-319 |
| issn | 1933-6934 1933-6942 |
| language | eng |
| recordid | cdi_crossref_primary_10_4161_fly_7464 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Apoptosis Binding Biology Bioscience Calcium Cancer Cell Cell Differentiation Cell Proliferation Central Nervous System - cytology Central Nervous System - embryology Cycle Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila melanogaster - physiology Genes, Homeobox - physiology Landes Organogenesis Proteins |
| title | Multiple roles for Hox genes in segment-specific shaping of CNS lineages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T19%3A08%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiple%20roles%20for%20Hox%20genes%20in%20segment-specific%20shaping%20of%20CNS%20lineages&rft.jtitle=Fly%20(Austin,%20Tex.)&rft.au=Rogulja-Ortmann,%20Ana&rft.date=2008-11-01&rft.volume=2&rft.issue=6&rft.spage=316&rft.epage=319&rft.pages=316-319&rft.issn=1933-6934&rft.eissn=1933-6942&rft_id=info:doi/10.4161/fly.7464&rft_dat=%3Cproquest_cross%3E66661942%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66661942&rft_id=info:pmid/19077542&rfr_iscdi=true |