Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells

Loss of nuclear progesterone receptors (PR) and low circulating progesterone levels are associated with increased ovarian cancer (OC) risk. However, PR are abundantly expressed in a significant percentage of serous and endometrioid ovarian tumors; patients with PR+ tumors typically experience longer...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2013-05, Vol.12 (9), p.1433-1449
Hauptverfasser:	Diep, Caroline, Charles, Nathan, Blake Gilks, C., Kalloger, Steve, Argenta, Peter, Lange, Carol A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AS1842856 breast cancer Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Cellular Senescence - drug effects Cellular Senescence - genetics Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Female Forkhead Box Protein O1 forkhead transcription factor Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXO1 Gene Expression Regulation, Neoplastic - drug effects Green Fluorescent Proteins - metabolism Humans Models, Biological ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology progesterone receptor progestin Progestins - pharmacology Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Binding - genetics Receptors, Progesterone - genetics Receptors, Progesterone - metabolism senescence Tumor Stem Cell Assay Up-Regulation - drug effects Up-Regulation - genetics
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