MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene

The microRNA miR-138 is dysregulated in several human cancers, but the underlying mechanism remains largely unknown. Here, we report that miR-138 is commonly underexpressed in nasopharyngeal carcinoma (NPC) specimens and NPC cell lines. The ectopic expression of miR-138 dramatically suppressed cell...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2012-07, Vol.11 (13), p.2495-2506
Hauptverfasser:	Liu, Xia, LV, Xiao-Bin, Wang, Xiao-Pai, Sang, Yi, Xu, Shuangbing, Hu, Kaishun, Wu, Mansi, Liang, Yi, Liu, Pan, Tang, Jianjun, Lu, Wen-Hua, Feng, Qi-Sheng, Chen, Li-Zhen, Qian, Chao-Nan, Bei, Jin-Xin, Kang, Tiebang, Zeng, Yi-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Binding Biology Bioscience Calcium Cancer Carcinoma Cell Cell Line, Tumor Cell Proliferation Cycle cyclin D1 (CCND1) Cyclin D1 - antagonists & inhibitors Cyclin D1 - genetics Cyclin D1 - metabolism G1 Phase Cell Cycle Checkpoints Humans Landes Mice Mice, Nude microarray microRNA MicroRNAs - metabolism MicroRNAs - therapeutic use miR-138 Nasopharyngeal Carcinoma nasopharyngeal carcinoma (NPC) Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Organogenesis Proteins RNA Interference RNA, Small Interfering - metabolism Transplantation, Heterologous tumor suppressor tumorigenesis Up-Regulation
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