Characterization of rare transforming KRAS mutations in sporadic colorectal cancer

KRAS mutational status has been shown to be a predictive biomarker of resistance to anti-EGFR monoclonal antibody (mAb) therapy in patients with metastatic colorectal cancer. We report the spectrum of KRAS mutation in 1506 patients with colorectal cancer and the identification and characterization o...

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Veröffentlicht in:	Cancer biology & therapy 2014-06, Vol.15 (6), p.768-776
Hauptverfasser:	Tong, Joanna HM, Lung, Raymond WM, Sin, Frankie MC, Law, Peggy PY, Kang, Wei, Chan, Anthony WH, Ma, Brigette BY, Mak, Tony WC, Ng, Simon SM, To, Ka Fai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Aged Aged, 80 and over Animals Base Sequence colorectal cancer Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Mutational Analysis Female Genetic Association Studies HEK293 Cells Humans INDEL Mutation KRAS Male Mice Mice, Inbred BALB C Mice, Nude Middle Aged Mutation, Missense Neoplasm Transplantation NIH 3T3 Cells Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Research Paper Sex Distribution Signal Transduction targeted therapy Young Adult
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