High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell

Overexpression of high-mobility group box 2 (HMGB2) is recently reported in several malignant cancers and was correlated with poor response to preoperative chemoradiotherapy of colorectal cancer patients. To enhance the chemoradiotherapy efficacy, the biological function of HMGB2 was investigated wi...

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Veröffentlicht in:	Cancer biology & therapy 2013-03, Vol.14 (3), p.213-221
Hauptverfasser:	Shin, Young-Joo, Kim, Mi-Sook, Kim, Moon-Sun, Lee, Joonseok, Kang, Miae, Jeong, Jae-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DNA Damage DNA Repair Gene Expression Regulation, Neoplastic - radiation effects Gene Knockdown Techniques HCT116 Cells HMGB2 HMGB2 Protein - genetics HT29 Cells Humans radiation Radiation Tolerance - genetics Research Paper Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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