TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells

A key step in the process of metastasis is the epithelial-to-mesenchymal transition (EMT). We hypothesized that epigenetic mechanisms play a key role in EMT and to test this hypothesis we analyzed global and gene-specific changes in DNA methylation during TGF-β-induced EMT in ovarian cancer cells. E...

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Veröffentlicht in:	Epigenetics 2014-11, Vol.9 (11), p.1461-1472
Hauptverfasser:	Cardenas, Horacio, Vieth, Edyta, Lee, Jiyoon, Segar, Mathew, Liu, Yunlong, Nephew, Kenneth P, Matei, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Azacitidine - analogs & derivatives Azacitidine - pharmacology Cadherins - genetics Cell Line, Tumor - drug effects Collagen Type I - genetics Collagen Type I, alpha 1 Chain CpG Islands - drug effects DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - drug effects DNA Methyltransferase 3A DNA Methyltransferase 3B EMT Enzyme Inhibitors - pharmacology Epigenesis, Genetic Epithelial-Mesenchymal Transition - drug effects Female Gene Expression Regulation, Neoplastic Humans ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Promoter Regions, Genetic Research Paper SGI-110 TGF-β Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology
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