Application of simplex lattice design for the development of extended release tablets of model drug diclofenac sodium

Simplex lattice design was applied to predict extent of drug release from extended release diclofenac sodium tablets. The effects of composition on dissolution rate were evaluated by varying the levels of hydroxypropyl methylcellulose, dicalcium phosphate and cornstarch via three component design. T...

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Veröffentlicht in:	Therapeutic delivery 2019-08, Vol.10 (8), p.515-525
Hauptverfasser:	Phadke, Shivaji, Kanekar, Tanvi, Gumaste, Suhas, Parikh, Vaishnavi
Format:	Artikel
Sprache:	eng
Schlagworte:	Delayed-Action Preparations Diclofenac - chemistry Diclofenac - metabolism diclofenac sodium Drug Compounding - methods Drug Liberation extended release hydroxypropyl methylcellulose Hypromellose Derivatives - chemistry optimization of drug release simplex lattice design Tablets - chemistry
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