Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia

Standard treatments have shown dismal activity against pancreatic cancer (PC), due in part to the development of a dense stroma (desmoplasia). This perspective discusses the development of the di-2-pyridylketone thiosemicarbazones that overcomes bidirectional oncogenic signaling between PC cells and...

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Veröffentlicht in:	Future medicinal chemistry 2022-07, Vol.14 (13), p.1005-1017
Hauptverfasser:	Richardson, D R, Azad, M Gholam, Afroz, R, Richardson, V, Dharmasivam, M
Format:	Artikel
Sprache:	eng
Schlagworte:	bidirectional oncogenic signaling Carcinogenesis Cell Cycle Proteins Cell Line, Tumor di-2-pyridylketone thiosemicarbazones Hedgehog Proteins Humans Intracellular Signaling Peptides and Proteins N-myc downstream-regulated gene 1 pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Sonic Hedgehog signaling Thiosemicarbazones - pharmacology
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