Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors

Antibiotic resistance is an alarming issue, as multidrug-resistant bacteria are growing worldwide, hence the decrease of therapeutic potential of available antibiotic arsenal. Among these bacteria, was pointed by the WHO in the pathogens list to be prioritized in drug development. We report the use...

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Veröffentlicht in:	Future medicinal chemistry 2020-01, Vol.12 (1), p.51-68
Hauptverfasser:	Asse Junior, Leonardo Rander, Kronenberger, Thales, Magalhães Serafim, Mateus Sá, Sousa, Yamara Viana, Franco, Isabella Drumond, Valli, Marilia, Silva Bolzani, Vanderlan da, Monteiro, Gustavo Claro, Bruno Prates, João Lucas, Kroon, Erna Geessien, Fernandes Mota, Bruno Eduardo, Santos Ferreira, Diego Dos, de Oliveira, Renata Barbosa, Maltarollo, Vinicius Gonçalves
Format:	Artikel
Sprache:	eng
Schlagworte:	antibacterial Antibacterial activity Antibiotic resistance Antimicrobial activity Antimicrobial agents Bacteria Binding sites Biological activity Datasets Drug development FabI inhibitors Fatty acids Laboratories Libraries ligand-based virtual screening MRSA Multidrug resistance Penicillin R&D Reductase Research & development similarity search Skin Staphylococcus infections
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