A validated capillary microsampling liquid chromatography–tandem mass spectrometry method for quantification of antisense oligonucleotides in mouse serum

Capillary microsampling (CMS) has been used for quantitative bioanalysis of small molecules; however, there is no report of applying this technique in the bioanalysis of antisense oligonucleotides (ASOs). A CMS liquid chromatography–tandem mass spectrometry method was successfully developed and vali...

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Veröffentlicht in:	Bioanalysis 2023-06, Vol.15 (12), p.683-694
Hauptverfasser:	Yuan, Long, Dupuis, Jean-François, Vrionis, Valerie, Mekhssian, Kevork, Magee, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense oligonucleotides capillary microsampling (CMS) hybridization LC–MS/MS microsampling quantitative bioanalysis
Online-Zugang:	Volltext
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