Simultaneous assaying of NLG919, tryptophan and kynurenine by ultra-high performance LC–MS in pharmacokinetics and biodistribution studies

Indocyanine2,3-dioxygenase (IDO) is an enzyme that can catalyze the metabolism of tryptophan (Trp) into kynurenine (Kyn), thus inhibiting the tumor immune microenvironment. Based on its inhibitor, NLG919 (NLG), the authors developed a new immunomodulatory polymer micelle and established and verified...

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Veröffentlicht in:	Bioanalysis 2023-03, Vol.15 (6), p.315-330
Hauptverfasser:	Li, Juan, Cao, Yongjing, Zhang, Xiaojie, An, Min, Zhang, Juntao, Liu, Yanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Liquid - methods kynurenine Kynurenine - metabolism Mice Neoplasms NLG919 pharmacokinetics and biodistribution Tandem Mass Spectrometry - methods Tissue Distribution tryptophan Tryptophan - metabolism Tumor Microenvironment UPLC–MS/MS
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