Feasibility of using PALSAR technology as a signal amplifier for antibody bridging assay

The immunogenicity testing of oligonucleotide drugs using an antibody bridging assay has been scarcely investigated. We developed a highly sensitive antibody bridging assay model and assessed it using probe alteration link self-assembly reactions (PALSAR) technology as a signal amplifier. The concen...

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Veröffentlicht in:	Bioanalysis 2022-09, Vol.14 (17), p.1153-1163
Hauptverfasser:	Omori, Akane, Sekino, Tetsuo, Ideno, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody bridging assay antidrug antibodies immunogenicity study oligonucleotide drug PALSAR technology
Online-Zugang:	Volltext
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