Quantitation of reduced IL-33 levels in human serum: mitigating interference from endogenous binding partners

IL-33 is a potential therapeutic target but commercially available assays for the quantitation of systemic IL-33 have poor reliability. In commercial IL-33 kits, interference from endogenous binding partners (e.g., soluble ST2) causes under-quantitation. Mitigating this required acid dissociation an...

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Veröffentlicht in:	Bioanalysis 2021-12, Vol.13 (23), p.1751-1760
Hauptverfasser:	Zylstra, Joshua, Partridge, Michael A, Sumner, Giane
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma - blood Asthma - pathology bioanalysis biomarker Humans IL-33 Immunoassay Interleukin-1 Receptor-Like 1 Protein - chemistry Interleukin-1 Receptor-Like 1 Protein - metabolism Interleukin-33 - blood Interleukin-33 - chemistry Interleukin-33 - genetics Interleukin-33 - metabolism LBA Limit of Detection Oxidation-Reduction Protein Binding Reagent Kits, Diagnostic Recombinant Proteins - analysis Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Smoking total assay
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