Determination of cortisol in hair using UHPLC–MS/MS: application to patients admitted for ethanol dependence treatment

Cortisol hair levels can be used to evaluate chronic stress status. In this context, an improved UHPLC–MS/MS assay for the determination of cortisol in hair was developed and validated. Hair was extracted with methanol for 4 h at 25°C. Chromatographic run time was 5.5 min. The assay was linear in th...

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Veröffentlicht in:	Bioanalysis 2021-10, Vol.13 (20), p.1559-1568
Hauptverfasser:	Decker Soares, Daniella Rheingantz, Bastiani, Marcos Frank, Schneider, Anelise, Hahn, Roberta Zilles, Lizot, Lilian Feltraco, Perassolo, Magda Susana, Antunes, Marina Venzon, Linden, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcoholism - diagnosis Alcoholism - metabolism Chromatography, High Pressure Liquid - methods chronic ethanol consumption cortisol ethyl glucuronide Female hair Hair - chemistry Humans Hydrocortisone - analysis Male Middle Aged Tandem Mass Spectrometry - methods UHPLC–MS/MS
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