Practical aspect of dimer adduct formation in small-molecule drug analysis with LC-MS/MS

Since the MS/MS based detection of small-molecule drugs with poor or even no ion fragmentation is a challenge in bioanalysis, alternative MS/MS detection strategies were in focus of this study and applied in the field of forensic toxicology. Analyte quantification with liquid chromatography-tandem m...

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Veröffentlicht in:	Bioanalysis 2021-11, Vol.13 (22), p.1671-1679
Hauptverfasser:	Dziadosz, Marek, Klintschar, Michael, Teske, Joerg
Format:	Artikel
Sprache:	eng
Schlagworte:	adduct formation adduct fragmentation adduct quantification Biochemical Research Methods Biochemistry & Molecular Biology Calibration Chemistry Chemistry, Analytical Chromatography, High Pressure Liquid - standards dimer formation Dimerization Humans LC-MS/MS Life Sciences & Biomedicine Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - standards Physical Sciences quadratic calibration Science & Technology Small Molecule Libraries - analysis Small Molecule Libraries - chemistry Tandem Mass Spectrometry - standards valproic acid Valproic Acid - blood Valproic Acid - chemistry
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