Whole blood stability evaluation of monoclonal antibody therapeutics using volumetric absorptive microsampling

Volumetric absorptive microsampling (VAMS) is increasingly utilized for both nonclinical and clinical pharmacokinetic studies. Currently, VAMS is employed as the sampling method for the detection of antibodies for coronavirus disease 2019. Biotherapeutics whole blood stability on VAMS presents as a...

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Veröffentlicht in:	Bioanalysis 2021-04, Vol.13 (8), p.621-629
Hauptverfasser:	Li, Hua, Myzithras, Maria, Bolella, Erica, Leonard, Antony, Ahlberg, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - blood Antibodies, Monoclonal - pharmacokinetics antibody therapeutics Blood Specimen Collection - methods Daclizumab - blood Daclizumab - pharmacokinetics Dried Blood Spot Testing - methods Drug Storage Light Rats Tandem Mass Spectrometry Temperature Trastuzumab - blood Trastuzumab - pharmacokinetics VAMS volumetric absorptive microsampling whole blood stability
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