A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS

An LC-MS/MS assay for the quantitation of liraglutide, a peptide-based injectable glucagon-like peptide-1 receptor agonist, has been developed as a convenient alternative to the enzyme-linked immunosorbent assay, and used to characterize liraglutide pharmacokinetics in cynomolgus monkeys. Assay cali...

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Veröffentlicht in:	Bioanalysis 2018-03, Vol.10 (5), p.357-368
Hauptverfasser:	King-Ahmad, Amanda J, Kalgutkar, Amit S, Niosi, Mark, Eng, Heather, Holliman, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	agonist bioanalytical ELISA enzyme-linked immunosorbent assay GLP-1 glucagon-like peptide-1 LC-MS/MS liquid chromatography tandem mass Spectrometry liraglutide monkey pharmacokinetics plasma receptor
Online-Zugang:	Volltext
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