Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP-HPLC method

Asenapine maleate (ASPM) is a newer antipsychotic drug available as a sublingual tablet in the market. To investigate the pharmacokinetic and tissue distribution study of ASPM following oral administration in rats, reversed-phase HPLC method was developed and validated. ASPM was extracted from plasm...

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Veröffentlicht in:	Bioanalysis 2017-07, Vol.9 (14), p.1037-1047
Hauptverfasser:	Managuli, Renuka S, Gourishetti, Karthik, Shenoy, Rekha R, Koteshwara, Kunnatur B, Reddy, Meka Sreenivasa, Mutalik, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals asenapine maleate Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods Heterocyclic Compounds, 4 or More Rings - pharmacokinetics Limit of Detection liquid-liquid extraction Male pharmacokinetic Rats Rats, Sprague-Dawley Reproducibility of Results RP-HPLC Tissue Distribution
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