Simultaneous determination of six tyrosine kinase inhibitors in human plasma using HPLC-Q-Orbitrap mass spectrometry

Gefitinib, erlotinib, icotinib, crizotinib, lapatinib and apatinib are targeted cancer therapy agents acting through inhibition of tyrosine kinase. Method for quantifying these six drugs in human plasma of patients was required. An HPLC-Q-Orbitrap method (based on HPLC-MS/MS) was developed and valid...

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Veröffentlicht in:	Bioanalysis 2017-06, Vol.9 (12), p.925-935
Hauptverfasser:	Ni, Mao-Wei, Zhou, Jie, Li, Hui, Chen, Wei, Mou, Han-Zhou, Zheng, Zhi-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Chemical Analysis - methods Chromatography, High Pressure Liquid - methods Humans Limit of Detection Linear Models method development Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Q-Orbitrap Tandem Mass Spectrometry - methods therapeutic drug monitoring Time Factors
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