From patient to tube: the importance of physiologically relevant quantitative bioanalytical assays

Circulating drug concentrations (clinical or preclinical) underly many interactions between industry and regulators; expressing safety coverage, pharmacokinetic-pharmacodynamic relationships or defining bioequivalence and dosing regimens. Accurate and precise measurement of these circulating concent...

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Veröffentlicht in:	Bioanalysis 2016-12, Vol.8 (24), p.2595-2604
Hauptverfasser:	Summerfield, Scott, Barfield, Matthew, Spooner, Neil, White, Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	biological matrix Blood Specimen Collection Chromatography, High Pressure Liquid - standards circulating concentration Drug Monitoring Drug Stability Hemolysis Humans Pharmaceutical Preparations - blood Pharmaceutical Preparations - metabolism Pharmaceutical Preparations - standards physiologically relevant Quality Control Tandem Mass Spectrometry - standards Temperature
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