Determination of riociguat and its major human metabolite M-1 in human plasma by stable-isotope dilution LCMS/MS

Riociguat (BAY 63-2521) is an oral NO-independent as well as NO-synergistic stimulator of soluble guanylate cyclase (sGC) for the treatment of pulmonary hypertension. BAY 60-4552 (M-1) is its pharmacologically active major metabolite. An isotope dilution LC-ESI-MS/MS method has been developed and va...

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Veröffentlicht in:	Bioanalysis 2015, Vol.7 (2), p.193-205
Hauptverfasser:	Gnoth, Mark-Jean, Hopfe, Peter-Michael, Czembor, Waldemar
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Chemical Analysis - methods Calibration Chromatography, High Pressure Liquid - standards Humans Isotope Labeling Pyrazoles - blood Pyrazoles - metabolism Pyrazoles - standards Pyrimidines - blood Pyrimidines - metabolism Pyrimidines - standards Quality Control Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - standards
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