Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects

We developed an HPLC-MS/MS method to quantify tamoxifen (2.5-250 ng/ml) and its metabolite (Z)-endoxifen (0.5-50 ng/ml) in dried blood spots. Extraction recovery of both analytes from Whatman DMPK-A cards was 100% and consistent over time, however, recovery of (Z)-endoxifen from Whatman 903 cards wa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioanalysis 2014-01, Vol.6 (22), p.2999-3009
Hauptverfasser:	Jager, Nynke Gl, Rosing, Hilde, Schellens, Jan Hm, Beijnen, Jos H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Hormonal - blood Chromatography, High Pressure Liquid - methods Humans Quality Control Reference Standards Tamoxifen - analogs & derivatives Tamoxifen - blood Tandem Mass Spectrometry - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!