Simultaneous determination of dipyrone metabolites in rat hypothalamus, cerebrospinal fluid and plasma samples by LC-MS/MS

After oral administration dipyrone is rapidly hydrolyzed to 4-methylaminoantipyrine, which is absorbed and further metabolized to 4-formylaminoantipyrine and to 4-aminoantipyrine, which is acetylated by a polymorphic N-acetyltransferase system to 4-acetylaminoantipyrine. To evaluate the presence of...

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Veröffentlicht in:	Bioanalysis 2013-11, Vol.5 (21), p.2631-2645
Hauptverfasser:	Aguiar, Fernando A, Malvar, David do C, Vaz, Artur de L L, Calixto, Leandro A, Clososki, Giuliano C, de Gaitani, Cristiane M, de Souza, Glória E P, Jabor, Valquíria A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, High Pressure Liquid - methods Dipyrone - analysis Dipyrone - blood Dipyrone - cerebrospinal fluid Dipyrone - metabolism Hypothalamus - chemistry Hypothalamus - metabolism Male Rats Rats, Wistar Tandem Mass Spectrometry - methods
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