Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle
The effect of increased dietary copper (Cu), molybdenum (Mo) and sulfur (S) on biliary Cu and zinc (Zn) excretion was studied in four Angus and four Simmental heifers surgically prepared for bile collection. Initially, two of each breed were fed a low(L)-Cu and two a high(H)-Cu diet for 2 mo. All an...
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| Veröffentlicht in: | Canadian journal of animal science 1994-06, Vol.74 (2), p.315-325 |
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| creator | Gooneratne, S.R Symonds, H.W Bailey, J.V Christensen, D.A |
| description | The effect of increased dietary copper (Cu), molybdenum (Mo) and sulfur (S) on biliary Cu and zinc (Zn) excretion was studied in four Angus and four Simmental heifers surgically prepared for bile collection. Initially, two of each breed were fed a low(L)-Cu and two a high(H)-Cu diet for 2 mo. All animals were then transferred sequentially to diets containing LCu–HS for 1.5 mo, HCu–HS for 2 mo, HCu–HMo for 2 mo and HCu–HMo–HS for 2 mo. Bile flow and biliary Cu and Zn concentration were measured on two consecutive days each month. Plasma Cu concentrations were measured once monthly. Biliary Cu concentrations (mg L
−1
) and bile Cu excretion (mg 6h
−1
) were greater (P |
| doi_str_mv | 10.4141/cjas94-043 |
| format | Article |
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−1
) and bile Cu excretion (mg 6h
−1
) were greater (P < 0.05) in cattle fed the HCu diet than those fed the LCu diet. The greatest overall excretion of Cu (P < 0.05) occurred during feeding of the HCu–HMo–HS diet. Dietary concentrations of Cu, Mo or S did not affect the biliary Zn concentration except in cattle fed the LCu diet when Zn excretion was low. The present study describes for the first time a breed difference in biliary Cu excretion in cattle. Biliary Cu concentration was higher (P < 0.001) in the Simmental cattle than in the Angus cattle. Biliary Cu excretion during the first day of each 2-d sampling period was significantly higher than during the second day. This was a combined effect of a greater bile flow (P < 0.005) and biliary Cu concentration (P < 0.05). In contrast, both biliary Zn concentration and biliary Zn excretion were higher (P < 0.0001) during the second day of sampling. Diet-related changes in plasma total Cu and the trichloroacetic acid (TCA) - soluble Cu were evident. The highest TCA-soluble Cu concentration was observed during feeding of the HCu diet. A decline in plasma Cu concentration occurred during HS feeding. A TCA-insoluble plasma Cu fraction could be detected only during HCu–HMo–HS feeding. These experiments support the view that at least one of the mechanisms by which excess dietary levels of Mo and S induce hypocuprosis in ruminants is by increasing biliary Cu excretion. Key words: Copper, molybdenum, sulfur, biliary excretion, cattle]]></description><identifier>ISSN: 0008-3984</identifier><identifier>EISSN: 1918-1825</identifier><identifier>DOI: 10.4141/cjas94-043</identifier><language>eng</language><subject>AZUFRE ; BILE DUCTS ; BILIARY SYSTEM ; BOVIN ; BREEDS (ANIMALS) ; CANAL BILIAIRE ; CATTLE ; CINC ; COBRE ; COMPLEMENT ALIMENTAIRE ; CONDUCTO BILIAR ; COPPER ; CUIVRE ; EXCRECION ; EXCRETION ; GANADO BOVINO ; MINERAL SUPPLEMENTS ; MOLIBDENO ; MOLYBDENE ; MOLYBDENUM ; RACE (ANIMAL) ; RAZAS (ANIMALES) ; SOUFRE ; SULPHUR ; SUPLEMENTOS ; SUPPLEMENTS ; ZINC</subject><ispartof>Canadian journal of animal science, 1994-06, Vol.74 (2), p.315-325</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c216t-5a80aed3fac4779d47841805959c39d26ff6d27969293ad5230acfd9700d36d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Gooneratne, S.R</creatorcontrib><creatorcontrib>Symonds, H.W</creatorcontrib><creatorcontrib>Bailey, J.V</creatorcontrib><creatorcontrib>Christensen, D.A</creatorcontrib><title>Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle</title><title>Canadian journal of animal science</title><description><![CDATA[The effect of increased dietary copper (Cu), molybdenum (Mo) and sulfur (S) on biliary Cu and zinc (Zn) excretion was studied in four Angus and four Simmental heifers surgically prepared for bile collection. Initially, two of each breed were fed a low(L)-Cu and two a high(H)-Cu diet for 2 mo. All animals were then transferred sequentially to diets containing LCu–HS for 1.5 mo, HCu–HS for 2 mo, HCu–HMo for 2 mo and HCu–HMo–HS for 2 mo. Bile flow and biliary Cu and Zn concentration were measured on two consecutive days each month. Plasma Cu concentrations were measured once monthly. Biliary Cu concentrations (mg L
−1
) and bile Cu excretion (mg 6h
−1
) were greater (P < 0.05) in cattle fed the HCu diet than those fed the LCu diet. The greatest overall excretion of Cu (P < 0.05) occurred during feeding of the HCu–HMo–HS diet. Dietary concentrations of Cu, Mo or S did not affect the biliary Zn concentration except in cattle fed the LCu diet when Zn excretion was low. The present study describes for the first time a breed difference in biliary Cu excretion in cattle. Biliary Cu concentration was higher (P < 0.001) in the Simmental cattle than in the Angus cattle. Biliary Cu excretion during the first day of each 2-d sampling period was significantly higher than during the second day. This was a combined effect of a greater bile flow (P < 0.005) and biliary Cu concentration (P < 0.05). In contrast, both biliary Zn concentration and biliary Zn excretion were higher (P < 0.0001) during the second day of sampling. Diet-related changes in plasma total Cu and the trichloroacetic acid (TCA) - soluble Cu were evident. The highest TCA-soluble Cu concentration was observed during feeding of the HCu diet. A decline in plasma Cu concentration occurred during HS feeding. A TCA-insoluble plasma Cu fraction could be detected only during HCu–HMo–HS feeding. These experiments support the view that at least one of the mechanisms by which excess dietary levels of Mo and S induce hypocuprosis in ruminants is by increasing biliary Cu excretion. Key words: Copper, molybdenum, sulfur, biliary excretion, cattle]]></description><subject>AZUFRE</subject><subject>BILE DUCTS</subject><subject>BILIARY SYSTEM</subject><subject>BOVIN</subject><subject>BREEDS (ANIMALS)</subject><subject>CANAL BILIAIRE</subject><subject>CATTLE</subject><subject>CINC</subject><subject>COBRE</subject><subject>COMPLEMENT ALIMENTAIRE</subject><subject>CONDUCTO BILIAR</subject><subject>COPPER</subject><subject>CUIVRE</subject><subject>EXCRECION</subject><subject>EXCRETION</subject><subject>GANADO BOVINO</subject><subject>MINERAL SUPPLEMENTS</subject><subject>MOLIBDENO</subject><subject>MOLYBDENE</subject><subject>MOLYBDENUM</subject><subject>RACE (ANIMAL)</subject><subject>RAZAS (ANIMALES)</subject><subject>SOUFRE</subject><subject>SULPHUR</subject><subject>SUPLEMENTOS</subject><subject>SUPPLEMENTS</subject><subject>ZINC</subject><issn>0008-3984</issn><issn>1918-1825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEURYMoWKsbl66yFkeTSTJJlkNpVSi4sPuQ5qOkzGRKkgHrr3dsBVeXxz08LgeAe4yeKab4xex1lrRClFyAGZZYVFjU7BLMEEKiIlLQa3CT8346ecP4DOSl986UDAcPbXBFpyM0w-Hg0hPsh-64tS6OPdTRwjx2fkxwiHAbuvAPnsrvEA10Xya5EiYiRPgZ-t7FortT38bdmKHRpXTuFlx53WV395dzsFktN4u3av3x-r5o15WpcVMqpgXSzhKvDeVcWsoFxQIxyaQh0taN942tuWxkLYm2rCZIG28lR8iSxpI5eDy_NWnIOTmvDin0026Fkfq1pc621GRrgh_OsNeD0rsUslq0kiHMCCU_FG5nEA</recordid><startdate>199406</startdate><enddate>199406</enddate><creator>Gooneratne, S.R</creator><creator>Symonds, H.W</creator><creator>Bailey, J.V</creator><creator>Christensen, D.A</creator><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199406</creationdate><title>Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle</title><author>Gooneratne, S.R ; Symonds, H.W ; Bailey, J.V ; Christensen, D.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c216t-5a80aed3fac4779d47841805959c39d26ff6d27969293ad5230acfd9700d36d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>AZUFRE</topic><topic>BILE DUCTS</topic><topic>BILIARY SYSTEM</topic><topic>BOVIN</topic><topic>BREEDS (ANIMALS)</topic><topic>CANAL BILIAIRE</topic><topic>CATTLE</topic><topic>CINC</topic><topic>COBRE</topic><topic>COMPLEMENT ALIMENTAIRE</topic><topic>CONDUCTO BILIAR</topic><topic>COPPER</topic><topic>CUIVRE</topic><topic>EXCRECION</topic><topic>EXCRETION</topic><topic>GANADO BOVINO</topic><topic>MINERAL SUPPLEMENTS</topic><topic>MOLIBDENO</topic><topic>MOLYBDENE</topic><topic>MOLYBDENUM</topic><topic>RACE (ANIMAL)</topic><topic>RAZAS (ANIMALES)</topic><topic>SOUFRE</topic><topic>SULPHUR</topic><topic>SUPLEMENTOS</topic><topic>SUPPLEMENTS</topic><topic>ZINC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gooneratne, S.R</creatorcontrib><creatorcontrib>Symonds, H.W</creatorcontrib><creatorcontrib>Bailey, J.V</creatorcontrib><creatorcontrib>Christensen, D.A</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Canadian journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gooneratne, S.R</au><au>Symonds, H.W</au><au>Bailey, J.V</au><au>Christensen, D.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle</atitle><jtitle>Canadian journal of animal science</jtitle><date>1994-06</date><risdate>1994</risdate><volume>74</volume><issue>2</issue><spage>315</spage><epage>325</epage><pages>315-325</pages><issn>0008-3984</issn><eissn>1918-1825</eissn><abstract><![CDATA[The effect of increased dietary copper (Cu), molybdenum (Mo) and sulfur (S) on biliary Cu and zinc (Zn) excretion was studied in four Angus and four Simmental heifers surgically prepared for bile collection. Initially, two of each breed were fed a low(L)-Cu and two a high(H)-Cu diet for 2 mo. All animals were then transferred sequentially to diets containing LCu–HS for 1.5 mo, HCu–HS for 2 mo, HCu–HMo for 2 mo and HCu–HMo–HS for 2 mo. Bile flow and biliary Cu and Zn concentration were measured on two consecutive days each month. Plasma Cu concentrations were measured once monthly. Biliary Cu concentrations (mg L
−1
) and bile Cu excretion (mg 6h
−1
) were greater (P < 0.05) in cattle fed the HCu diet than those fed the LCu diet. The greatest overall excretion of Cu (P < 0.05) occurred during feeding of the HCu–HMo–HS diet. Dietary concentrations of Cu, Mo or S did not affect the biliary Zn concentration except in cattle fed the LCu diet when Zn excretion was low. The present study describes for the first time a breed difference in biliary Cu excretion in cattle. Biliary Cu concentration was higher (P < 0.001) in the Simmental cattle than in the Angus cattle. Biliary Cu excretion during the first day of each 2-d sampling period was significantly higher than during the second day. This was a combined effect of a greater bile flow (P < 0.005) and biliary Cu concentration (P < 0.05). In contrast, both biliary Zn concentration and biliary Zn excretion were higher (P < 0.0001) during the second day of sampling. Diet-related changes in plasma total Cu and the trichloroacetic acid (TCA) - soluble Cu were evident. The highest TCA-soluble Cu concentration was observed during feeding of the HCu diet. A decline in plasma Cu concentration occurred during HS feeding. A TCA-insoluble plasma Cu fraction could be detected only during HCu–HMo–HS feeding. These experiments support the view that at least one of the mechanisms by which excess dietary levels of Mo and S induce hypocuprosis in ruminants is by increasing biliary Cu excretion. Key words: Copper, molybdenum, sulfur, biliary excretion, cattle]]></abstract><doi>10.4141/cjas94-043</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Canadian journal of animal science, 1994-06, Vol.74 (2), p.315-325 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | AZUFRE BILE DUCTS BILIARY SYSTEM BOVIN BREEDS (ANIMALS) CANAL BILIAIRE CATTLE CINC COBRE COMPLEMENT ALIMENTAIRE CONDUCTO BILIAR COPPER CUIVRE EXCRECION EXCRETION GANADO BOVINO MINERAL SUPPLEMENTS MOLIBDENO MOLYBDENE MOLYBDENUM RACE (ANIMAL) RAZAS (ANIMALES) SOUFRE SULPHUR SUPLEMENTOS SUPPLEMENTS ZINC |
| title | Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle |
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