Comparison of the Efficacy of Intra-articular Platelet-rich Plasma with Intra-articular Steroid in the Management of Pain due to Sacroiliac Joint Dysfunction

Background: Platelet-rich plasma (PRP) has proved to be beneficial due to its remodeling property in various conditions in the past. When given intra-articularly, it may also provide adequate analgesia in low back pain. Aims: This study was aimed to compare the efficacy between intra-articular sacroiliac joint (SIJ) injection of PRP and steroid in the management of SIJ dysfunction pain. Materials and Methods: This prospective, randomized parallel group study was conducted for 24 months period at a tertiary care hospital. A total of 50 patients above 18 years were included in the study and allocated into two groups (n = 25) by computer randomization. Patients in the respective group received sacroiliac intra-articular injection of either autologous PRP or triamcinolone (steroid). For the primary outcome, the Numerical Rating Scale Score was recorded preprocedure and postprocedure at the 24 h, 1st, 3rd, and 6th month. The need for any rescue analgesia or repeat injection during the study period was considered the secondary outcome. Results: At the 1st, 3rd, and 6th month postprocedure, 100%, 88%, and 76% of patients, respectively, obtained significant pain relief after injection of PRP. In contrast, at 3rd and 6th month postprocedure, only 20% and 28%, respectively, had short-term pain relief in the steroid group. Conclusions: Single intra-articular injection of PRP provides significant pain relief and functional improvement in patients with SIJ pain.