LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation

LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation

Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chromatography research international 2011-02, Vol.2011 (2011), p.1-8
Hauptverfasser: Martins, Magda T., Paim, Clésio S., Steppe, Martin
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 8
container_issue 2011
container_start_page 1
container_title Chromatography research international
container_volume 2011
creator Martins, Magda T.
Paim, Clésio S.
Steppe, Martin
description Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (r2=0.9999). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The t-student test proved that the LC and UV methods are interchangeable.
doi_str_mv 10.4061/2011/860168
format Article
fullrecord <record><control><sourceid>emarefa_cross</sourceid><recordid>TN_cdi_crossref_primary_10_4061_2011_860168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>504053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1728-11c39ed3fbfee1c7c87f92ff423e4d43f0b8f7e1fd639599d97dddadaebd95f23</originalsourceid><addsrcrecordid>eNqF0MFLwzAUBvAgCo65k2chZ6XuJWmb5ijTqdChB-e1ZMl7LrK2knaI__02K7v6Lu_B9-MdPsYuBdymkIupBCGmRQ4iL07YSIKBRGUCTo83yHM26bpP2E-mjdHpiC3KGbeN58t3vsB-3fqOUxt5aeu2j-EjNMjvscdYh8b2oW14aPjr2sbaOtz2wdkNn7ex3m5-0wt2RnbT4eRvj9ly_vA2e0rKl8fn2V2ZOKFlkQjhlEGvaEWIwmlXaDKSKJUKU58qglVBGgX5XJnMGG-09956iytvMpJqzG6Gvy62XReRqq8Yaht_KgHVoYzqUEY1lLHX14Neh8bb7_APvhow7gmSPeIMUsiU2gGEPWja</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation</title><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Martins, Magda T. ; Paim, Clésio S. ; Steppe, Martin</creator><contributor>Takeuchi, Toyohide</contributor><creatorcontrib>Martins, Magda T. ; Paim, Clésio S. ; Steppe, Martin ; Takeuchi, Toyohide</creatorcontrib><description>Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (r2=0.9999). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The t-student test proved that the LC and UV methods are interchangeable.</description><identifier>ISSN: 2090-3502</identifier><identifier>ISSN: 2090-3510</identifier><identifier>EISSN: 2090-3510</identifier><identifier>DOI: 10.4061/2011/860168</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><ispartof>Chromatography research international, 2011-02, Vol.2011 (2011), p.1-8</ispartof><rights>Copyright © 2011 Magda T. Martins et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1728-11c39ed3fbfee1c7c87f92ff423e4d43f0b8f7e1fd639599d97dddadaebd95f23</citedby><cites>FETCH-LOGICAL-c1728-11c39ed3fbfee1c7c87f92ff423e4d43f0b8f7e1fd639599d97dddadaebd95f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><contributor>Takeuchi, Toyohide</contributor><creatorcontrib>Martins, Magda T.</creatorcontrib><creatorcontrib>Paim, Clésio S.</creatorcontrib><creatorcontrib>Steppe, Martin</creatorcontrib><title>LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation</title><title>Chromatography research international</title><description>Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (r2=0.9999). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The t-student test proved that the LC and UV methods are interchangeable.</description><issn>2090-3502</issn><issn>2090-3510</issn><issn>2090-3510</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqF0MFLwzAUBvAgCo65k2chZ6XuJWmb5ijTqdChB-e1ZMl7LrK2knaI__02K7v6Lu_B9-MdPsYuBdymkIupBCGmRQ4iL07YSIKBRGUCTo83yHM26bpP2E-mjdHpiC3KGbeN58t3vsB-3fqOUxt5aeu2j-EjNMjvscdYh8b2oW14aPjr2sbaOtz2wdkNn7ex3m5-0wt2RnbT4eRvj9ly_vA2e0rKl8fn2V2ZOKFlkQjhlEGvaEWIwmlXaDKSKJUKU58qglVBGgX5XJnMGG-09956iytvMpJqzG6Gvy62XReRqq8Yaht_KgHVoYzqUEY1lLHX14Neh8bb7_APvhow7gmSPeIMUsiU2gGEPWja</recordid><startdate>20110217</startdate><enddate>20110217</enddate><creator>Martins, Magda T.</creator><creator>Paim, Clésio S.</creator><creator>Steppe, Martin</creator><general>Hindawi Puplishing Corporation</general><general>SAGE-Hindawi Access to Research</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20110217</creationdate><title>LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation</title><author>Martins, Magda T. ; Paim, Clésio S. ; Steppe, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1728-11c39ed3fbfee1c7c87f92ff423e4d43f0b8f7e1fd639599d97dddadaebd95f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Magda T.</creatorcontrib><creatorcontrib>Paim, Clésio S.</creatorcontrib><creatorcontrib>Steppe, Martin</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><jtitle>Chromatography research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, Magda T.</au><au>Paim, Clésio S.</au><au>Steppe, Martin</au><au>Takeuchi, Toyohide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation</atitle><jtitle>Chromatography research international</jtitle><date>2011-02-17</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2090-3502</issn><issn>2090-3510</issn><eissn>2090-3510</eissn><abstract>Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (r2=0.9999). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The t-student test proved that the LC and UV methods are interchangeable.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><doi>10.4061/2011/860168</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-3502
ispartof Chromatography research international, 2011-02, Vol.2011 (2011), p.1-8
issn 2090-3502
2090-3510
2090-3510
language eng
recordid cdi_crossref_primary_10_4061_2011_860168
source Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
title LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T10%3A20%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-emarefa_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LC%20and%20UV%20Methods%20for%20Lamotrigine%20Determination%20in%20Pharmaceutical%20Formulation&rft.jtitle=Chromatography%20research%20international&rft.au=Martins,%20Magda%20T.&rft.date=2011-02-17&rft.volume=2011&rft.issue=2011&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=2090-3502&rft.eissn=2090-3510&rft_id=info:doi/10.4061/2011/860168&rft_dat=%3Cemarefa_cross%3E504053%3C/emarefa_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true