Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity

CD8 T cell differentiation is orchestrated by dynamic metabolic changes that direct activation, proliferation, cytotoxic function, and epigenetic changes. We report that the BTB-ZF family transcriptional repressor Zbtb20 negatively regulates CD8 T cell metabolism and memory differentiation in mice....

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Veröffentlicht in:	The Journal of immunology (1950) 2020-11, Vol.205 (10), p.2649-2666
Hauptverfasser:	Sun, Yanbo, Preiss, Nicholas K, Valenteros, Kristine B, Kamal, Yasmin, Usherwood, Young-Kwang, Frost, H Robert, Usherwood, Edward J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Cell Differentiation - genetics Cell Differentiation - immunology Disease Models, Animal Energy Metabolism - genetics Energy Metabolism - immunology Gene Expression Regulation, Neoplastic - immunology Glycolysis - genetics Glycolysis - immunology Humans Immunologic Memory - genetics Listeria monocytogenes - immunology Listeriosis - immunology Listeriosis - microbiology Lymphocyte Activation Mice Mice, Knockout Mitochondria - metabolism Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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