A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria

We have designed and produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. We used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-12, Vol.183 (11), p.7268-7277
Hauptverfasser:	Kaba, Stephen A, Brando, Clara, Guo, Qin, Mittelholzer, Christian, Raman, Senthilkumar, Tropel, David, Aebi, Ueli, Burkhard, Peter, Lanar, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antibody Affinity Antigens, Protozoan - immunology Enzyme-Linked Immunosorbent Assay Epitopes, B-Lymphocyte - immunology Female Immunoglobulin G - blood Immunoglobulin G - immunology Malaria - immunology Malaria - prevention & control Malaria Vaccines - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Nanoparticles - therapeutic use Peptides - therapeutic use Plasmodium berghei - immunology
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