Cutting Edge: H-2Ld Class I Molecule Protects an HIV N-Extended Epitope from In Vitro Trimming by Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing
In the classical MHC class I Ag presentation pathway, antigenic peptides derived from viral proteins by multiple proteolytic cleavages are transported to the endoplasmic reticulum lumen and are then exposed to ami-nopeptidase activity. In the current study, a long MHC class I natural ligand recogniz...
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| Veröffentlicht in: | The Journal of immunology (1950) 2010-04, Vol.184 (7), p.3351-3355 |
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| container_end_page | 3355 |
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| container_issue | 7 |
| container_start_page | 3351 |
| container_title | The Journal of immunology (1950) |
| container_volume | 184 |
| creator | Infantes, Susana Samino, Yolanda Lorente, Elena Jimenez, Mercedes Garcia, Ruth Del Val, Margarita Lopez, Daniel |
| description | In the classical MHC class I Ag presentation pathway, antigenic peptides derived from viral proteins by multiple proteolytic cleavages are transported to the endoplasmic reticulum lumen and are then exposed to ami-nopeptidase activity. In the current study, a long MHC class I natural ligand recognized by cytotoxic T lymphocytes was used to study the kinetics of degradation by aminopeptidase. The in vitro data indicate that this N-extended peptide is efficiently trimmed to a 9-mer, unless its binding to the MHC molecules protects the full-length peptide. |
| doi_str_mv | 10.4049/jimmunol.0901560 |
| format | Article |
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| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Cutting Edge: H-2Ld Class I Molecule Protects an HIV N-Extended Epitope from In Vitro Trimming by Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing |
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