Disseminated and Rapidly Fatal Tuberculosis in Mice Bearing a Defective Allele at IFN Regulatory Factor 8

The interferon regulatory factor (IRF) family member IRF-8 participates in IFN-gamma-dependent transcriptional activation of genes containing in their promoter regions IFN-stimulated response element or IFN-gamma activation site elements. To test the role of IRF-8 in host defenses against tuberculos...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-03, Vol.182 (5), p.3008-3015
Hauptverfasser:	Marquis, Jean-Francois, LaCourse, Ronald, Ryan, Lynn, North, Robert J, Gros, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution - genetics Amino Acid Substitution - immunology Animals Arginine - genetics Cysteine - genetics Female Genetic Predisposition to Disease Interferon Regulatory Factors - deficiency Interferon Regulatory Factors - genetics Interferons - biosynthesis Interferons - genetics Liver - immunology Liver - microbiology Liver - pathology Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Mutation - immunology Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Spleen - immunology Spleen - microbiology Spleen - pathology Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - mortality Tuberculosis, Pulmonary - pathology Virulence
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