Transcriptome-To-Metabolome™ Biosimulation Reveals Human Hippocampal Hypometabolism with Age and Alzheimer’s Disease

The authors had validated a proprietary method, Transcriptome-To-Metabolome™ (TTM™) Biosimulation, for using the transcriptome to determine parameters for kinetic biosimulation of 16 core metabolic pathways. In vivo and in silico evidence confirmed that hippocampal cholesterol metabolism decreases w...

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Veröffentlicht in:	International journal of knowledge discovery in bioinformatics 2011-04, Vol.2 (2), p.1-18
Hauptverfasser:	Phelix, Clyde F, LeBaron, Richard G, Roberson, Dawnlee J, Villanueva, Rosa E, Villareal, Greg, Rahimi, Omid B, Siedlak, Sandra, Zhu, Xiongwei, Perry, George
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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