Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes
Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of P...
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| Veröffentlicht in: | Journal of microbiology and biotechnology 2020, 30(1), , pp.21-30 |
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| creator | Choi, Dae-Hye Han, Joon-Hee Yu, Keun-Hyung Hong, Min Lee, Sun-Yeop Park, Ka-Hee Lee, Soo-Ung Kwon, Tae-Hyung |
| description | Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPAR gamma, C/EBP alpha) and lipogenesis- related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-kappa B, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders. |
| doi_str_mv | 10.4014/jmb.1910.10040 |
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In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPAR gamma, C/EBP alpha) and lipogenesis- related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-kappa B, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders.</description><identifier>ISSN: 1017-7825</identifier><identifier>EISSN: 1738-8872</identifier><identifier>DOI: 10.4014/jmb.1910.10040</identifier><identifier>PMID: 31838799</identifier><language>eng</language><publisher>SEOUL: Korean Soc Microbiology & Biotechnology</publisher><subject>3T3-L1 Cells ; Adipocytes - drug effects ; Adipogenesis - drug effects ; Animals ; Anti-Obesity Agents - pharmacology ; Antioxidants - pharmacology ; Biotechnology & Applied Microbiology ; Fallopia japonica - chemistry ; Life Sciences & Biomedicine ; Lipid Metabolism - drug effects ; Lipogenesis - drug effects ; Mice ; Microbiology ; Obesity - prevention & control ; Plant Extracts - pharmacology ; Research article ; Science & Technology ; 생물학</subject><ispartof>Journal of Microbiology and Biotechnology, 2020, 30(1), , pp.21-30</ispartof><rights>Copyright©2020 by The Korean Society for Microbiology and Biotechnology 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>19</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000509743200003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c424t-148457dccc29710cf0683ce178322f98e68d4c8e2e435f91119bd694a3cdbeb93</citedby><cites>FETCH-LOGICAL-c424t-148457dccc29710cf0683ce178322f98e68d4c8e2e435f91119bd694a3cdbeb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728287/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728287/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31838799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002554078$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Dae-Hye</creatorcontrib><creatorcontrib>Han, Joon-Hee</creatorcontrib><creatorcontrib>Yu, Keun-Hyung</creatorcontrib><creatorcontrib>Hong, Min</creatorcontrib><creatorcontrib>Lee, Sun-Yeop</creatorcontrib><creatorcontrib>Park, Ka-Hee</creatorcontrib><creatorcontrib>Lee, Soo-Ung</creatorcontrib><creatorcontrib>Kwon, Tae-Hyung</creatorcontrib><title>Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes</title><title>Journal of microbiology and biotechnology</title><addtitle>J MICROBIOL BIOTECHN</addtitle><addtitle>J Microbiol Biotechnol</addtitle><description>Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPAR gamma, C/EBP alpha) and lipogenesis- related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-kappa B, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes - drug effects</subject><subject>Adipogenesis - drug effects</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Fallopia japonica - chemistry</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipogenesis - drug effects</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Obesity - prevention & control</subject><subject>Plant Extracts - pharmacology</subject><subject>Research article</subject><subject>Science & Technology</subject><subject>생물학</subject><issn>1017-7825</issn><issn>1738-8872</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV9r2zAUxc3YWLtur3sceh3Dqf7Zkl4GJnRdIdBR0mdhX8uJWlsKlpw1X2Cfu0rShfVtT_dc6XeOECfLPhM845jwy4ehmRGVNoIxx2-ycyKYzKUU9G3SmIhcSFqcZR9CeMC4JFSW77MzRiSTQqnz7E_lovVPtq1dRLVr0X7PbxsTbNyhCqLd2mhNQL5Dv3y_W3k3DQimsEmWmOTVUxxriCiuRz-t1qjqe7O1dQp1e8_CJjDlwDRM_cupQ2zJ8gVBVWs3HnbRhI_Zu67ug_n0Mi-y-x9Xy_nPfHF7fTOvFjlwymNOuOSFaAGAKkEwdLiUDAwRklHaKWlK2XKQhhrOik4RQlTTlorXDNrGNIpdZF-PuW7s9CNY7Wt7mCuvH0dd3S1vdFkWBS5xYr8f2c3UDKYF49JPe70Z7VCPu4Pz9Y2z65Sz1UpQSaVIAbNjAIw-hNF0Jy_Bet-eTu3pfXv60F4yfPn3xRP-t64EfDsCv03juwDWODAnDGNcYCU4o0lhlmj5__TcxkM9cz-5yJ4BZrm5QA</recordid><startdate>20200128</startdate><enddate>20200128</enddate><creator>Choi, Dae-Hye</creator><creator>Han, Joon-Hee</creator><creator>Yu, Keun-Hyung</creator><creator>Hong, Min</creator><creator>Lee, Sun-Yeop</creator><creator>Park, Ka-Hee</creator><creator>Lee, Soo-Ung</creator><creator>Kwon, Tae-Hyung</creator><general>Korean Soc Microbiology & Biotechnology</general><general>Korean Society for Microbiology and Biotechnology</general><general>한국미생물·생명공학회</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>20200128</creationdate><title>Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes</title><author>Choi, Dae-Hye ; Han, Joon-Hee ; Yu, Keun-Hyung ; Hong, Min ; Lee, Sun-Yeop ; Park, Ka-Hee ; Lee, Soo-Ung ; Kwon, Tae-Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-148457dccc29710cf0683ce178322f98e68d4c8e2e435f91119bd694a3cdbeb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes - drug effects</topic><topic>Adipogenesis - drug effects</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Fallopia japonica - chemistry</topic><topic>Life Sciences & Biomedicine</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipogenesis - drug effects</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Obesity - prevention & control</topic><topic>Plant Extracts - pharmacology</topic><topic>Research article</topic><topic>Science & Technology</topic><topic>생물학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Dae-Hye</creatorcontrib><creatorcontrib>Han, Joon-Hee</creatorcontrib><creatorcontrib>Yu, Keun-Hyung</creatorcontrib><creatorcontrib>Hong, Min</creatorcontrib><creatorcontrib>Lee, Sun-Yeop</creatorcontrib><creatorcontrib>Park, Ka-Hee</creatorcontrib><creatorcontrib>Lee, Soo-Ung</creatorcontrib><creatorcontrib>Kwon, Tae-Hyung</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Journal of microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Dae-Hye</au><au>Han, Joon-Hee</au><au>Yu, Keun-Hyung</au><au>Hong, Min</au><au>Lee, Sun-Yeop</au><au>Park, Ka-Hee</au><au>Lee, Soo-Ung</au><au>Kwon, Tae-Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes</atitle><jtitle>Journal of microbiology and biotechnology</jtitle><stitle>J MICROBIOL BIOTECHN</stitle><addtitle>J Microbiol Biotechnol</addtitle><date>2020-01-28</date><risdate>2020</risdate><volume>30</volume><issue>1</issue><spage>21</spage><epage>30</epage><pages>21-30</pages><issn>1017-7825</issn><eissn>1738-8872</eissn><abstract>Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPAR gamma, C/EBP alpha) and lipogenesis- related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-kappa B, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders.</abstract><cop>SEOUL</cop><pub>Korean Soc Microbiology & Biotechnology</pub><pmid>31838799</pmid><doi>10.4014/jmb.1910.10040</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3T3-L1 Cells Adipocytes - drug effects Adipogenesis - drug effects Animals Anti-Obesity Agents - pharmacology Antioxidants - pharmacology Biotechnology & Applied Microbiology Fallopia japonica - chemistry Life Sciences & Biomedicine Lipid Metabolism - drug effects Lipogenesis - drug effects Mice Microbiology Obesity - prevention & control Plant Extracts - pharmacology Research article Science & Technology 생물학 |
| title | Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes |
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