Decrease in neutralizing antibody titers after SARS-CoV-2 vaccination in hemodialysis patients and the booster effect of a third vaccination

We measured anti-SP-IgG antibody titers 6 months after the second dose of a SARS-CoV-2 vaccine (BNT162b2) and 1 month after the third vaccination in 105 hemodialysis patients, and examined the booster effect of the third vaccination. The mean anti-SP-IgG antibody titer at 6 months after the second v...

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Veröffentlicht in:Nihon Toseki Igakkai Zasshi 2022, Vol.55(10), pp.589-593
Hauptverfasser: Ooyama, Keiko, Kaneko, Naoyuki, Kitazumi, Yumiko, Yokozeki, Mieko, Ooyama, Hiroshi, Fujimori, Shin
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container_issue 10
container_start_page 589
container_title Nihon Toseki Igakkai Zasshi
container_volume 55
creator Ooyama, Keiko
Kaneko, Naoyuki
Kitazumi, Yumiko
Yokozeki, Mieko
Ooyama, Hiroshi
Fujimori, Shin
description We measured anti-SP-IgG antibody titers 6 months after the second dose of a SARS-CoV-2 vaccine (BNT162b2) and 1 month after the third vaccination in 105 hemodialysis patients, and examined the booster effect of the third vaccination. The mean anti-SP-IgG antibody titer at 6 months after the second vaccination was 499.2±619.4 AU/mL, which was about one-tenth lower than that seen 1 month after the second vaccination;however, 7 patients exhibited negative conversion (<50 AU/mL). The mean anti-SP-IgG antibody titer at 1 month after the third vaccination, including the cases involving negative conversion, had increased 85.7 times to 42,800.9±58,666.2 AU/mL, confirming the booster effect of the third vaccination. However, although the causes were unknown, there were two unresponsive cases.
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subjects anti-SP-IgG antibody
booster effect
COVID-19
hemodialysis patients
SARS-CoV-2 vaccine
title Decrease in neutralizing antibody titers after SARS-CoV-2 vaccination in hemodialysis patients and the booster effect of a third vaccination
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