Polymorphism of the angiotensin-converting enzyme gene and the prognosis of chronic hemodialysis patients

Polymorphism of the angiotensin-converting enzyme gene and the prognosis of chronic hemodialysis patients

To investigate the implications of insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in the prognosis of hemodialysis patients, 218 patients on chronic hemodialysis were followed for one year after determining the ACE genotype. The numbers of patients with II, ID...

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Veröffentlicht in:Nihon Toseki Igakkai Zasshi 1999/06/28, Vol.32(6), pp.997-1003
Hauptverfasser: Futoh, Yasuo, Ishimitsu, Toshihiko, Ogawa, Yoshiichi, Teranishi, Megumi, Matsuoka, Hiroaki
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container_end_page 1003
container_issue 6
container_start_page 997
container_title Nihon Toseki Igakkai Zasshi
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creator Futoh, Yasuo
Ishimitsu, Toshihiko
Ogawa, Yoshiichi
Teranishi, Megumi
Matsuoka, Hiroaki
description To investigate the implications of insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in the prognosis of hemodialysis patients, 218 patients on chronic hemodialysis were followed for one year after determining the ACE genotype. The numbers of patients with II, ID and DD genotypes were 93, 92 and 33, respectively, and the frequencies of I and D alleles were 0.64 and 0.36 respectively. Background characteristics such as age, gender, causative disease of renal failure and complications of cardiovascular diseases at the time of study entry were comparable among the three genotype groups. Serum ACE activity was significantly higher in DD than in II or ID, however, the plasma angiotensin II concentration was not significantly different among the three groups. During the one-year follow-up period, 24 of the 218 patients (11.0%) had died. The mortality of hemodialysis patients was significantly associated with high age (p
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The numbers of patients with II, ID and DD genotypes were 93, 92 and 33, respectively, and the frequencies of I and D alleles were 0.64 and 0.36 respectively. Background characteristics such as age, gender, causative disease of renal failure and complications of cardiovascular diseases at the time of study entry were comparable among the three genotype groups. Serum ACE activity was significantly higher in DD than in II or ID, however, the plasma angiotensin II concentration was not significantly different among the three groups. During the one-year follow-up period, 24 of the 218 patients (11.0%) had died. The mortality of hemodialysis patients was significantly associated with high age (p<0.001), male gender (p<0.03), absence of alcohol consumption (p<0.001), high cardio-thoracic ratio on chest roentgenography (p<0.02), low serum Na concentration (p<0.03) and high plasma angiotensin II concentration (p<0.003). The mortality was not significantly different among the three ACE genotypes, however, the incidence of fatal and non-fatal cardiovascular events was significantly higher in DD than in II and ID (II 3.3%, ID 6.5%, DD 15.2%; p<0.03). The findings suggested that the DD genotype of the ACE gene polymorphism is a risk factor of cardiovascular complications in hemodialysis patients.]]></description><identifier>ISSN: 1340-3451</identifier><identifier>EISSN: 1883-082X</identifier><identifier>DOI: 10.4009/jsdt.32.997</identifier><language>eng</language><publisher>The Japanese Society for Dialysis Therapy</publisher><ispartof>Nihon Toseki Igakkai Zasshi, 1999/06/28, Vol.32(6), pp.997-1003</ispartof><rights>The Japanese Society for Dialysis Therapy</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Futoh, Yasuo</creatorcontrib><creatorcontrib>Ishimitsu, Toshihiko</creatorcontrib><creatorcontrib>Ogawa, Yoshiichi</creatorcontrib><creatorcontrib>Teranishi, Megumi</creatorcontrib><creatorcontrib>Matsuoka, Hiroaki</creatorcontrib><title>Polymorphism of the angiotensin-converting enzyme gene and the prognosis of chronic hemodialysis patients</title><title>Nihon Toseki Igakkai Zasshi</title><addtitle>Nihon Toseki Igakkai Zasshi</addtitle><description><![CDATA[To investigate the implications of insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in the prognosis of hemodialysis patients, 218 patients on chronic hemodialysis were followed for one year after determining the ACE genotype. 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The mortality was not significantly different among the three ACE genotypes, however, the incidence of fatal and non-fatal cardiovascular events was significantly higher in DD than in II and ID (II 3.3%, ID 6.5%, DD 15.2%; p<0.03). 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title Polymorphism of the angiotensin-converting enzyme gene and the prognosis of chronic hemodialysis patients
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